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Stockholders' Equity (Tables)
 12 Months Ended
Dec. 31, 2017
Equity [Abstract]  
Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan
The number of remaining shares authorized to be issued under the various equity plans are as follows as of December 31, 2017:
 
 2003 Equity Plan
 
 2009 Equity Plan
 
 2015 Equity Plan
Shares Authorized for Issuance
25,000

 
899,500

 
440,000

2016 Evergreen increase of shares
—

 
—

 
226,932

2017 Evergreen increase of shares
 
 
 
 
328,232

Outstanding Stock Options
(5,006
)
 
(432,916
)
 
(634,577
)
Exercised Stock Options
(925
)
 
(8,093
)
 
(3,835
)
Restricted stock or equity grants issued under Equity Plans
(8,922
)
 
(156,467
)
 
—

Shares Expired
(10,147
)
 
(302,024
)
 
(314,254
)
Total common shares remaining to be issued under the Equity Plans
—

 
—

 
42,498
Schedule of Share-based Compensation, Stock Options, Activity
The following table summarizes the activity for stock options and warrants for the year ended December 31, 2017:
 
Stock Options
 
Warrants
 
Shares
 
Weighted Average Exercise Price
 
Weighted Average Remaining Contractual Term (Years)
 
Aggregate Intrinsic Value (In Thousands)
 
Shares
 
Weighted Average Exercise Price
 
Weighted Average Remaining Contractual Term (Years)
 
Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2016
952,790

 
$
39.90

 
7.60
 
$
—

 
388,062

 
$
76.50

 
1.24
 
$
—

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Changes during the Year:
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Granted
448,057

 
$
11.70

 
 
 
 
 
—

 
$
—

 
 
 
 
Exercised
(3,835
)
 
$
4.70

 
 
 
 
 
—

 
$
—

 
 
 
 
Forfeited
(244,413
)
 
$
18.80

 
 
 
 
 
(1,937
)
 
$
700.00

 
 
 
 
Expired
(80,100
)
 
$
35.80

 
 
 
 
 
(176,307
)
 
$
103.90

 
 
 
 
Outstanding at December 31, 2017
1,072,499

 
$
33.50

 
4.76
 
$
0.1

 
209,818

 
$
53.20

 
0.95
 
$
—

Vested at December 31, 2017 or expected to vest in the future
1,072,107

 
$
33.5

 
4.76
 
$
0.1

 
209,818

 
$
53.20

 
0.95
 
$
—

Exercisable at December 31, 2017
1,063,759

 
$
32.9

 
4.77
 
$
0.1

 
209,818

 
$
53.20

 
0.95
 
$
—

The following table summarizes the components of share-based compensation expense for the years ended December 31, 2017 and 2016 ($ in thousands):
 
Year Ended December 31,
 
2017
 
2016
Research and development
$
268.9

 
$
262.3

General and administrative
1,694.3

 
1,511.5

Discontinued operations
888.9

 
830.6

Total share-based compensation expense
$
2,852.1

 
$
2,604.3
Restricted Stock
During the years ended December 31, 2017 and 2016, the Company issued restricted stock for services as follows ($ in thousands, except share data):
 
 
 
 
 
2017
 
2016
 
Number of Restricted Stock Issued
 
181,908

 
126,849

 
Value of Restricted Stock Issued
 
$
627.7

 
$
698.1