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Stockholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2018
Equity [Abstract] |
Schedule of Share-based Compensation, Stock Options, Activity | The following table summarizes the activity for stock options and warrants for the year ended December 31, 2018:
| Stock Options |  | Warrants
| Shares |  | Weighted Average Exercise Price |  | Weighted Average Remaining Contractual Term (Years) |  | Aggregate Intrinsic Value (In Thousands) |  | Shares |  | Weighted Average Exercise Price |  | Weighted Average Remaining Contractual Term (Years) |  | Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2017 | 1,072,499 |  |  | $ | 33.50 |  |  | 4.76 |  | $ | 0.1 |  |  | 209,818 |  |  | $ | 53.20 |  |  | 0.95 |  | $ | — |
Changes during the Year: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Granted | 157,360 |  |  | $ | 4.00 |  |  |  |  |  |  | — |  |  | $ | — |  |  |  |  |
Exercised | (77,498 | ) |  | $ | 4.60 |  |  |  |  |  |  | — |  |  | $ | — |  |  |  |  |
Forfeited | (3,030 | ) |  | $ | 3.80 |  |  |  |  |  |  | — |  |  | $ | — |  |  |  |  |
Expired | (130,801 | ) |  | $ | 32.50 |  |  |  |  |  |  | (179,818 | ) |  | $ | 60.40 |  |  |  |  |
Outstanding at December 31, 2018 | 1,018,530 |  |  | $ | 30.50 |  |  | 5.30 |  | $ | 3.3 |  |  | 30,000 |  |  | $ | 5.90 |  |  | 4.19 |  | $ | — |
Vested at December 31, 2018 or expected to vest in the future | 1,008,918 |  |  | $ | 30.80 |  |  | 5.26 |  | $ | 3.3 |  |  | 30,000 |  |  | $ | 5.90 |  |  | 4.19 |  | $ | — |
Exercisable at December 31, 2018 | 895,861 |  |  | $ | 34.20 |  |  | 4.78 |  | $ | 3.3 |  |  | 30,000 |  |  | $ | 5.90 |  |  | 4.19 |  | $ | — |
The following table summarizes the components of share-based compensation expense for the years ended December 31, 2018 and 2017 ($ in thousands):
| Year Ended December 31,
| 2018 |  | 2017
Research and development | $ | 446 |  |  | $ | 269 |
General and administrative | 2,007 |  |  | 1,694 |
Discontinued operations | — |  |  | 889 |
Total share-based compensation expense | $ | 2,453 |  |  | $ | 2,852 |
Restricted Stock | During the years ended December 31, 2018 and 2017, the Company issued restricted stock for services as follows ($ in thousands, except share data):
| 2018 |  | 2017
Number of Restricted Stock Issued | 91,740 |  |  | 181,908 |
Value of Restricted Stock Issued | $ | 347.7 |  |  | $ | 627.7 |

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