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Stockholders' Equity - Activity for Stock Options and Warrants (Details) - USD ($)
 12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Stock Options, Shares    
Outstanding, beginning balance (shares) 1,018,530  
Granted (shares) 209,346  
Exercised (shares) (240)  
Forfeited (shares) (2,625)  
Expired (shares) (180,594)  
Outstanding, ending balance (shares) 1,044,417 1,018,530
Vested or expected to vest (shares) 1,028,387  
Exercisable (shares) 804,407  
Stock Options, Weighted Average Exercise Price    
Outstanding, beginning balance (in dollars per share) $ 30.50  
Granted (in dollars per share) 4.86  
Exercised (in dollars per share) 3.54  
Forfeited (in dollars per share) 4.63  
Expired (in dollars per share) 71.92  
Outstanding, ending balance (in dollars per share) 18.31 $ 30.50
Vested or expected to vest (in dollars per share) 18.52  
Exercisable (in dollars per share) $ 22.41  
Stock Options, Weighted Average Contractual Term and Intrinsic Value    
Stock options outstanding, weighted average remaining contractual term (in years) 6 years 22 days 5 years 3 months 18 days
Stock options vested or expected to vest, weighted average remaining contractual term (in years) 6 years 4 days  
Stock options exercisable, weighted average remaining contractual term (in years) 5 years 3 months 4 days  
Stock options outstanding, aggregate intrinsic value $ 0 $ 3,300
Stock options exercisable, aggregate intrinsic value 0  
Stock options vested or expected to vest, aggregate intrinsic value $ 0  
Warrants, Shares    
Warrants outstanding, beginning balance (shares) 30,000  
Warrants granted (shares) 0  
Warrants exercised (shares) 0  
Warrants forfeited (shares) 0  
Warrants expired (shares) 0  
Warrants outstanding, ending balance (shares) 30,000 30,000
Warrants vested or expected to vest (shares) 30,000  
Warrants exercisable (shares) 30,000  
Warrants, Weighted Average Exercise Price    
Warrants outstanding, beginning balance (in dollars per share) $ 5.90  
Warrants granted (in dollars per share) 0.00  
Warrants exercised (in dollars per share) 0.00  
Warrants forfeited (in dollars per share) 0.00  
Warrants expired (in dollars per share) 0.00  
Warrants outstanding, ending balance (in dollars per share) 5.89 $ 5.90
Warrants vested or expected to vest (in dollars per share) 5.89  
Warrants exercisable (in dollars per share) $ 5.89  
Warrants, Weighted Average Contractual Term and Intrinsic Value    
Warrants outstanding, weighted average remaining contractual term (in years) 3 years 2 months 9 days 4 years 2 months 9 days
Warrants vested or expected to vest, weighted average remaining contractual term (in years) 3 years 2 months 9 days  
Warrants exercisable, weighted average remaining contractual term (in years) 3 years 2 months 9 days  
Warrants outstanding, aggregate intrinsic value $ 0 $ 0
Warrants vested or expected to vest, aggregate intrinsic value 0  
Warrants exercisable, aggregate intrinsic value $ 0