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Stockholders' Equity - Stock Options and Warrants (Details) - USD ($) $ / shares in Units, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019
Stock Options, Shares |  |
Outstanding, beginning balance (shares) | 1,044,417 |
Granted (shares) | 248,176 |
Exercised (shares) | 0 |
Forfeited (shares) | (86,251) |
Expired (shares) | (242,642) |
Outstanding, ending balance (shares) | 963,700 | 1,044,417
Vested or expected to vest (shares) | 949,200 |
Exercisable (shares) | 714,426 |
Stock Options, Weighted Average Exercise Price |  |
Outstanding, beginning balance (in dollars per share) | $ 18.31 |
Granted (in dollars per share) | 3.20 |
Exercised (in dollars per share) | 0 |
Forfeited (in dollars per share) | 3.83 |
Expired (in dollars per share) | 22.57 |
Outstanding, ending balance (in dollars per share) | 14.64 | $ 18.31
Vested or expected to vest (in dollars per share) | 14.81 |
Exercisable (in dollars per share) | $ 18.42 |
Stock Options, Weighted Average Contractual Term and Intrinsic Value |  |
Stock options outstanding, weighted average remaining contractual term (in years) | 5 years 10 months 9 days | 6 years 21 days
Stock options vested or expected to vest, weighted average remaining contractual term (in years) | 5 years 9 months 25 days |
Stock options exercisable, weighted average remaining contractual term (in years) | 4 years 11 months 4 days |
Stock options outstanding, aggregate intrinsic value | $ 0 | $ 0
Stock options exercisable, aggregate intrinsic value | 0 |
Stock options vested or expected to vest, aggregate intrinsic value | $ 0 |
Warrants, Shares |  |
Warrants outstanding, beginning balance (shares) | 30,000 |
Warrants granted (shares) | 2,608,355 |
Warrants exercised (shares) | 0 |
Warrants forfeited (shares) | 0 |
Warrants expired (shares) | 0 |
Warrants outstanding, ending balance (shares) | 2,638,355 | 30,000
Warrants vested or expected to vest (shares) | 2,638,355 |
Warrants exercisable (shares) | 2,638,355 |
Warrants, Weighted Average Exercise Price |  |
Warrants outstanding, beginning balance (in dollars per share) | $ 5.89 |
Warrants granted (in dollars per share) | 2.14 |
Warrants exercised (in dollars per share) | 0 |
Warrants forfeited (in dollars per share) | 0 |
Warrants expired (in dollars per share) | 0 |
Warrants outstanding, ending balance (in dollars per share) | 2.18 | $ 5.89
Warrants vested or expected to vest (in dollars per share) | 2.18 |
Warrants exercisable (in dollars per share) | $ 2.18 |
Warrants, Weighted Average Contractual Term and Intrinsic Value |  |
Warrants outstanding, weighted average remaining contractual term (in years) | 4 years 11 months 23 days | 3 years 2 months 8 days
Warrants vested or expected to vest, weighted average remaining contractual term (in years) | 4 years 11 months 23 days |
Warrants exercisable, weighted average remaining contractual term (in years) | 4 years 11 months 23 days |
Warrants outstanding, aggregate intrinsic value | $ 0 | $ 0
Warrants vested or expected to vest, aggregate intrinsic value | 0 |
Warrants exercisable, aggregate intrinsic value | $ 0 |

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