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Stockholders' Equity - Stock Options and Warrants (Details) - USD ($)
$ / shares in Units, $ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Stock Options, Shares    
Outstanding, beginning balance (shares) 1,044,417  
Granted (shares) 248,176  
Exercised (shares) 0  
Forfeited (shares) (86,251)  
Expired (shares) (242,642)  
Outstanding, ending balance (shares) 963,700 1,044,417
Vested or expected to vest (shares) 949,200  
Exercisable (shares) 714,426  
Stock Options, Weighted Average Exercise Price    
Outstanding, beginning balance (in dollars per share) $ 18.31  
Granted (in dollars per share) 3.20  
Exercised (in dollars per share) 0  
Forfeited (in dollars per share) 3.83  
Expired (in dollars per share) 22.57  
Outstanding, ending balance (in dollars per share) 14.64 $ 18.31
Vested or expected to vest (in dollars per share) 14.81  
Exercisable (in dollars per share) $ 18.42  
Stock Options, Weighted Average Contractual Term and Intrinsic Value    
Stock options outstanding, weighted average remaining contractual term (in years) 5 years 10 months 9 days 6 years 21 days
Stock options vested or expected to vest, weighted average remaining contractual term (in years) 5 years 9 months 25 days  
Stock options exercisable, weighted average remaining contractual term (in years) 4 years 11 months 4 days  
Stock options outstanding, aggregate intrinsic value $ 0 $ 0
Stock options exercisable, aggregate intrinsic value 0  
Stock options vested or expected to vest, aggregate intrinsic value $ 0  
Warrants, Shares    
Warrants outstanding, beginning balance (shares) 30,000  
Warrants granted (shares) 2,608,355  
Warrants exercised (shares) 0  
Warrants forfeited (shares) 0  
Warrants expired (shares) 0  
Warrants outstanding, ending balance (shares) 2,638,355 30,000
Warrants vested or expected to vest (shares) 2,638,355  
Warrants exercisable (shares) 2,638,355  
Warrants, Weighted Average Exercise Price    
Warrants outstanding, beginning balance (in dollars per share) $ 5.89  
Warrants granted (in dollars per share) 2.14  
Warrants exercised (in dollars per share) 0  
Warrants forfeited (in dollars per share) 0  
Warrants expired (in dollars per share) 0  
Warrants outstanding, ending balance (in dollars per share) 2.18 $ 5.89
Warrants vested or expected to vest (in dollars per share) 2.18  
Warrants exercisable (in dollars per share) $ 2.18  
Warrants, Weighted Average Contractual Term and Intrinsic Value    
Warrants outstanding, weighted average remaining contractual term (in years) 4 years 11 months 23 days 3 years 2 months 8 days
Warrants vested or expected to vest, weighted average remaining contractual term (in years) 4 years 11 months 23 days  
Warrants exercisable, weighted average remaining contractual term (in years) 4 years 11 months 23 days  
Warrants outstanding, aggregate intrinsic value $ 0 $ 0
Warrants vested or expected to vest, aggregate intrinsic value 0  
Warrants exercisable, aggregate intrinsic value $ 0