<SEC-DOCUMENT>0001140361-22-027002.txt : 20220915
<SEC-HEADER>0001140361-22-027002.hdr.sgml : 20220915
<ACCEPTANCE-DATETIME>20220726165048
<PRIVATE-TO-PUBLIC>
ACCESSION NUMBER:		0001140361-22-027002
CONFORMED SUBMISSION TYPE:	CORRESP
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20220726

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CALADRIUS BIOSCIENCES, INC.
		CENTRAL INDEX KEY:			0000320017
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MISC HEALTH & ALLIED SERVICES, NEC [8090]
		IRS NUMBER:				222343568
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		CORRESP

	BUSINESS ADDRESS:	
		STREET 1:		110 ALLEN ROAD
		STREET 2:		SECOND FLOOR
		CITY:			BASKING RIDGE
		STATE:			NJ
		ZIP:			07920
		BUSINESS PHONE:		908-229-2590

	MAIL ADDRESS:	
		STREET 1:		110 ALLEN ROAD
		STREET 2:		SECOND FLOOR
		CITY:			BASKING RIDGE
		STATE:			NJ
		ZIP:			07920

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CALADRIUS BIOSCIENCES, INC.
		DATE OF NAME CHANGE:	20170808

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Caladrius Biosciences, Inc.
		DATE OF NAME CHANGE:	20150608

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NeoStem, Inc.
		DATE OF NAME CHANGE:	20060906
</SEC-HEADER>
<DOCUMENT>
<TYPE>CORRESP
<SEQUENCE>1
<FILENAME>filename1.htm
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    <div style="text-align: center; font-weight: bold;">Caladrius Biosciences, Inc.</div>
    <div style="text-align: center; font-weight: bold;">110 Allen Road, 2nd Floor</div>
    <div style="text-align: center; font-weight: bold;">Basking Ridge, New Jersey 07920</div>
    <div><br>
    </div>
    <div>July 26, 2022</div>
    <div><br>
    </div>
    <div style="font-weight: bold;">VIA EDGAR</div>
    <div><br>
    </div>
    <div>United States Securities and Exchange Commission</div>
    <div>Division of Corporation Finance</div>
    <div>100 F Street, N.E.</div>
    <div>Washington, D.C. 20549</div>
    <div><br>
    </div>
    <div><font style="font-weight: bold;">RE:</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160; <font style="font-weight: bold;">Caladrius
        Biosciences, Inc.</font></div>
    <div style="text-indent: 36pt; font-weight: bold;">Registration Statement on Form S-4 File No. 333-265638</div>
    <div style="text-indent: 36pt; font-weight: bold;"><u>Request for Acceleration of Effectiveness</u></div>
    <div><br>
    </div>
    <div>Ladies and Gentlemen:</div>
    <div> <br>
    </div>
    <div style="text-indent: 36pt;">In accordance with Rule 461 promulgated under the Securities Act of 1933, as amended, Caladrius Biosciences, Inc. (the &#8220;<u>Company</u>&#8221;) hereby requests acceleration of the effective date of the Registration Statement on Form S-4 (File No. 333-265638), as amended (the &#8220;<u>Registration Statement</u>&#8221;), so that it may become effective at 5:00 p.m. Washington, D.C. time on July 28, 2022, or as soon as possible thereafter.</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">The Company hereby authorizes Jeffrey P. Schultz, Esq. of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. to orally modify or withdraw
      this request for acceleration.</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">The Company respectfully requests that it be notified of such effectiveness by a telephone call to Attorney Schultz at (212) 692-6732 and
      that such effectiveness also be confirmed in writing. Any questions regarding this request may be addressed to Attorney Schultz.</div>
    <div style="text-indent: 36pt;"> <br>
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    <div style="text-indent: 36pt;">
      <table id="zab1452000ec641009f4bb436c4258f8e" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

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              <div>&#160;</div>
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              <div style="text-align: left; font-family: 'Times New Roman',Times,serif;">Very truly yours,</div>
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              <div>&#160;</div>
            </td>
            <td style="width: 50%;">
              <div>&#160;</div>
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              <div>&#160;</div>
            </td>
            <td style="width: 50%;">
              <div style="text-align: left; font-family: 'Times New Roman',Times,serif;">CALADRIUS BIOSCIENCES, INC.</div>
            </td>
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              <div>&#160;</div>
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              <div>&#160;</div>
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              <div>&#160;</div>
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            <td style="width: 50%; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: left;"><font style="font-family: 'Times New Roman',Times,serif;">/s/ David J. Mazzo, Ph.D.</font><br>
              </div>
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            <td rowspan="1" style="width: 50.00%;">&#160;</td>
            <td rowspan="1" style="width: 50%;">
              <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">David J. Mazzo, Ph.D.</div>
            </td>
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            <td rowspan="1" style="width: 50.00%;">&#160;</td>
            <td rowspan="1" style="width: 50%;">
              <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">President and Chief Executive Officer</div>
            </td>
          </tr>

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    </div>
    <div><br>
    </div>
    <div>cc:&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-style: italic;"><u>Caladrius Biosciences,
          Inc.</u></font></div>
    <div style="text-indent: 36pt;">Gregory B. Brown, M.D., <font style="font-style: italic;">Chairman of Board
        of Directors</font></div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; font-style: italic;"><u>Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.</u></div>
    <div style="text-indent: 36pt;">Jeffrey P. Schultz, Esq.</div>
    <div style="text-indent: 36pt;">Daniel A. Bagliebter, Esq.</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; font-style: italic;"><u>Procopio, Cory, Hargreaves &amp;Savitch LLP</u></div>
    <div style="text-indent: 36pt;">Paul Johnson, Esq.</div>
    <div style="text-indent: 36pt;">Christopher L. Tinen, Esq.</div>
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