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License Agreements (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Oct. 31, 2021 | Mar. 31, 2021 | Dec. 31, 2015 | Dec. 31, 2023 | Oct. 03, 2023 | Jul. 31, 2023 | Jun. 30, 2022 | Dec. 31, 2016
Impilo |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |
Investment owned (in shares) |  |  |  |  |  | 766,000 |  |
Sanford Burnham Prebys | Impilo |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |
Investment owned (in shares) |  |  |  |  | 191,500 |  |  |
Sanford Burnham Prebys | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |
Shares issued under license agreement (in shares) |  |  | 382,030 |  |  |  |  |
Annual license maintenance fee | $ 20 |  | $ 10 |  |  |  |  |
Annual license maintenance fee, year seven |  |  | 20 |  |  |  |  |
Potential milestone payments | $ 23,200 |  | $ 10,600 |  |  |  |  |
Royalties, net of sales | 4.00% |  | 4.00% |  |  |  |  |
Sublicensing fee |  |  |  |  |  |  |  | 25.00%
Option to terminate |  |  | 60 days |  |  |  |  |
Termination of contract, lapse of payment |  |  | 30 days |  |  |  |  |
Annual license maintenance fee, year four | $ 30 |  |  |  |  |  |  |
Sanford Burnham Prebys | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Minimum |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |
Sublicensing fee | 10.00% |  |  |  |  |  |  |
Sanford Burnham Prebys | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |
Sublicensing fee | 25.00% |  |  |  |  |  |  |
University of California at San Diego | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |
Potential milestone payments |  | $ 1,200 |  |  |  |  |  |
Royalties, net of sales |  | 1.50% |  |  |  |  |  |
Option to terminate |  | 90 days |  |  |  |  |  |
Time to cure default |  | 60 days |  |  |  |  |  |
University of California at San Diego | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Minimum |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |
Sublicensing fee |  |  |  |  |  |  | 10.00% |
University of California at San Diego | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |
Sublicensing fee |  | 20.00% |  |  |  |  |  |
Massachusetts Institute of Technology | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |
Annual license maintenance fee | $ 20 |  |  |  |  |  |  |
Potential milestone payments | $ 5,000 |  |  |  |  |  |  |
Royalties, net of sales | 2.00% |  |  |  |  |  |  |
Option to terminate | 6 months |  |  |  |  |  |  |
Termination of contract, lapse of payment | 30 days |  |  |  |  |  |  |
Annual license maintenance fee, year four | $ 50 |  |  |  |  |  |  |
Shares held by third party (in shares) |  |  |  | 43,236 |  |  |  |
Time to cure default | 60 days |  |  |  |  |  |  |
Annual license maintenance fee, years two and three | $ 25 |  |  |  |  |  |  |
Annual license maintenance fee, after first sale | 150 |  |  |  |  |  |  |
Change of control fee | $ 300 |  |  |  |  |  |  |
Massachusetts Institute of Technology | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | CEND |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |
Shares issued (in shares) |  |  |  | 43,236 |  |  |  |
Massachusetts Institute of Technology | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Minimum |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |
Sublicensing fee | 3.00% |  |  |  |  |  |  |
Massachusetts Institute of Technology | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |
Sublicensing fee | 20.00% |  |  |  |  |  |  |

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