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License Agreements (Details) - USD ($)
$ in Thousands
 1 Months Ended 12 Months Ended
Oct. 31, 2021
Mar. 31, 2021
Dec. 31, 2015
Dec. 31, 2023
Oct. 03, 2023
Jul. 31, 2023
Jun. 30, 2022
Dec. 31, 2016
Impilo                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Investment owned (in shares)           766,000    
Sanford Burnham Prebys | Impilo                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Investment owned (in shares)         191,500      
Sanford Burnham Prebys | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Shares issued under license agreement (in shares)     382,030          
Annual license maintenance fee $ 20   $ 10          
Annual license maintenance fee, year seven     20          
Potential milestone payments $ 23,200   $ 10,600          
Royalties, net of sales 4.00%   4.00%          
Sublicensing fee               25.00%
Option to terminate     60 days          
Termination of contract, lapse of payment     30 days          
Annual license maintenance fee, year four $ 30              
Sanford Burnham Prebys | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Minimum                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Sublicensing fee 10.00%              
Sanford Burnham Prebys | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Sublicensing fee 25.00%              
University of California at San Diego | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Potential milestone payments   $ 1,200            
Royalties, net of sales   1.50%            
Option to terminate   90 days            
Time to cure default   60 days            
University of California at San Diego | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Minimum                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Sublicensing fee             10.00%  
University of California at San Diego | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Sublicensing fee   20.00%            
Massachusetts Institute of Technology | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Annual license maintenance fee $ 20              
Potential milestone payments $ 5,000              
Royalties, net of sales 2.00%              
Option to terminate 6 months              
Termination of contract, lapse of payment 30 days              
Annual license maintenance fee, year four $ 50              
Shares held by third party (in shares)       43,236        
Time to cure default 60 days              
Annual license maintenance fee, years two and three $ 25              
Annual license maintenance fee, after first sale 150              
Change of control fee $ 300              
Massachusetts Institute of Technology | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | CEND                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Shares issued (in shares)       43,236        
Massachusetts Institute of Technology | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Minimum                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Sublicensing fee 3.00%              
Massachusetts Institute of Technology | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Sublicensing fee 20.00%