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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2024 | Mar. 31, 2023
Cash flows from operating activities: |  |
Net loss | $ (5,401) | $ (6,187)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Share-based compensation | 454 | 675
Depreciation and amortization | 46 | 48
Loss on disposal of fixed assets | 0 | 3
Loss from equity method investment | 100 | 0
Amortization/accretion on marketable securities | (152) | (167)
Changes in operating assets and liabilities: |  |
Prepaid and other current assets | (872) | (1,652)
Other assets | 41 | 167
Accounts payable, accrued liabilities and other liabilities | (1,243) | (1,083)
Net cash used in operating activities | (7,027) | (8,196)
Cash flows from investing activities: |  |
Purchase of marketable securities | (18,824) | (30,121)
Sale of marketable securities | 25,360 | 34,410
Investment in Impilo Therapeutics | (100) | 0
Net cash provided by investing activities | 6,436 | 4,289
Cash flows from financing activities: |  |
Tax withholding payments on net share settlement equity awards | (142) | (85)
Net cash used in financing activities | (142) | (85)
Effect of exchange rate changes on cash | (55) | (7)
Net decrease in cash and cash equivalents | (788) | (3,999)
Cash and cash equivalents at beginning of period | 22,593 | 32,154
Cash and cash equivalents at end of period | $ 21,805 | $ 28,155

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