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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2024 | Sep. 30, 2023
Cash flows from operating activities: |  |
Net loss | $ (15,375) | $ (15,475)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Share-based compensation | 1,018 | 1,565
Depreciation and amortization | 133 | 142
Loss on disposal of fixed assets | 0 | 3
Loss from equity method investment | 130 | 0
Amortization/accretion on marketable securities | (376) | (709)
Changes in operating assets and liabilities: |  |
Prepaid and other current assets | 1,572 | (314)
Other assets | 126 | 130
Accounts payable, accrued liabilities and other liabilities | (2,056) | (1,305)
Net cash used in operating activities | (14,828) | (15,963)
Cash flows from investing activities: |  |
Purchase of marketable securities | (43,953) | (77,355)
Sale of marketable securities | 55,927 | 93,171
Investment in Impilo Therapeutics | (130) | 0
Net cash provided by investing activities | 11,844 | 15,816
Cash flows from financing activities: |  |
Proceeds from exercise of options | 0 | 155
Tax withholding payments on net share settlement equity awards | (142) | (91)
Net proceeds from issuance of common stock | 32 | 297
Net cash (used in) provided by financing activities | (110) | 361
Effect of exchange rate changes on cash | 10 | 60
Net (decrease) increase in cash and cash equivalents | (3,084) | 274
Cash and cash equivalents at beginning of period | 22,593 | 32,154
Cash and cash equivalents at end of period | $ 19,509 | $ 32,428

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