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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023
Cash flows from operating activities:
Net loss	$ (15,375)	$ (15,475)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation	1,018	1,565
Depreciation and amortization	133	142
Loss on disposal of fixed assets	0	3
Loss from equity method investment	130	0
Amortization/accretion on marketable securities	(376)	(709)
Changes in operating assets and liabilities:
Prepaid and other current assets	1,572	(314)
Other assets	126	130
Accounts payable, accrued liabilities and other liabilities	(2,056)	(1,305)
Net cash used in operating activities	(14,828)	(15,963)
Cash flows from investing activities:
Purchase of marketable securities	(43,953)	(77,355)
Sale of marketable securities	55,927	93,171
Investment in Impilo Therapeutics	(130)	0
Net cash provided by investing activities	11,844	15,816
Cash flows from financing activities:
Proceeds from exercise of options	0	155
Tax withholding payments on net share settlement equity awards	(142)	(91)
Net proceeds from issuance of common stock	32	297
Net cash (used in) provided by financing activities	(110)	361
Effect of exchange rate changes on cash	10	60
Net (decrease) increase in cash and cash equivalents	(3,084)	274
Cash and cash equivalents at beginning of period	22,593	32,154
Cash and cash equivalents at end of period	$ 19,509	$ 32,428

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