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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023
Cash flows from operating activities: |  |
Net loss | $ (19,985,000) | $ (20,840,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Share-based compensation expense | 1,653,000 | 2,038,000
Depreciation and amortization | 174,000 | 189,000
Loss from equity method investment | 130,000 | 0
Loss on disposal of fixed assets | 0 | 3,000
Amortization/accretion on marketable securities | (455,000) | (960,000)
Changes in operating assets and liabilities: |  |
Accounts receivable | (900,000) | 0
Prepaid and other current assets | 852,000 | (824,000)
Other assets | 170,000 | 274,000
Accounts payable, accrued liabilities and other liabilities | (995,000) | 88,000
Net cash used in operating activities | (19,356,000) | (20,032,000)
Cash flows from investing activities: |  |
Purchase of marketable securities | (55,688,000) | (98,479,000)
Sales of marketable securities | 69,051,000 | 108,581,000
Investment in Impilo Therapeutics | (130,000) | 0
Net cash provided by investing activities | 13,233,000 | 10,102,000
Cash flows from financing activities: |  |
Proceeds from exercise of options | 0 | 155,000
Tax withholding payments on net share settlement equity awards | (274,000) | (91,000)
Net proceeds from issuance of common stock | 68,000 | 321,000
Net cash (used in) provided by financing activities | (206,000) | 385,000
Effect of exchange rate changes on cash | (55,000) | (16,000)
Net decrease in cash and cash equivalents | (6,384,000) | (9,561,000)
Cash and cash equivalents at beginning of year | 22,593,000 | 32,154,000
Cash and cash equivalents at end of year | $ 16,209,000 | $ 22,593,000

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