<SEC-DOCUMENT>0001140361-16-069575.txt : 20160613
<SEC-HEADER>0001140361-16-069575.hdr.sgml : 20160613
<ACCEPTANCE-DATETIME>20160613162011
ACCESSION NUMBER:		0001140361-16-069575
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20160601
FILED AS OF DATE:		20160613
DATE AS OF CHANGE:		20160613

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Clearside Biomedical, Inc.
		CENTRAL INDEX KEY:			0001539029
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				452437375
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1220 OLD ALPHARETTA RD
		STREET 2:		SUITE 300
		CITY:			ALPHARETTA
		STATE:			GA
		ZIP:			30005
		BUSINESS PHONE:		678-270-4005

	MAIL ADDRESS:	
		STREET 1:		1220 OLD ALPHARETTA RD
		STREET 2:		SUITE 300
		CITY:			ALPHARETTA
		STATE:			GA
		ZIP:			30005

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Chen Bihua
		CENTRAL INDEX KEY:			0001599214

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37783
		FILM NUMBER:		161710942

	MAIL ADDRESS:	
		STREET 1:		C/O CORMORANT ASSET MANAGEMENT, LLC
		STREET 2:		200 CLARENDON STREET, 52ND FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Cormorant Global Healthcare Master Fund, LP
		CENTRAL INDEX KEY:			0001618442
		STATE OF INCORPORATION:			E9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37783
		FILM NUMBER:		161710943

	BUSINESS ADDRESS:	
		STREET 1:		200 CLARENDON STREET
		STREET 2:		52ND FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		617-848-3429

	MAIL ADDRESS:	
		STREET 1:		200 CLARENDON STREET
		STREET 2:		52ND FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Cormorant Global Healthcare GP, LLC
		CENTRAL INDEX KEY:			0001618451
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37783
		FILM NUMBER:		161710944

	BUSINESS ADDRESS:	
		STREET 1:		100 HIGH STREET
		STREET 2:		SUITE 1105
		CITY:			BOSTON
		STATE:			DC
		ZIP:			02110
		BUSINESS PHONE:		617-848-3429

	MAIL ADDRESS:	
		STREET 1:		100 HIGH STREET
		STREET 2:		SUITE 1105
		CITY:			BOSTON
		STATE:			DC
		ZIP:			02110

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Cormorant Asset Management, LLC
		CENTRAL INDEX KEY:			0001583977
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37783
		FILM NUMBER:		161710945

	BUSINESS ADDRESS:	
		STREET 1:		200 CLARENDON STREET
		STREET 2:		52ND FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		857-702-0388

	MAIL ADDRESS:	
		STREET 1:		200 CLARENDON STREET
		STREET 2:		52ND FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>doc1.xml
<DESCRIPTION>FORM 3
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2016-06-01</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001539029</issuerCik>
        <issuerName>Clearside Biomedical, Inc.</issuerName>
        <issuerTradingSymbol>CLSD</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001583977</rptOwnerCik>
            <rptOwnerName>Cormorant Asset Management, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>200 CLARENDON STREET, 52ND FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02116</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001618451</rptOwnerCik>
            <rptOwnerName>Cormorant Global Healthcare GP, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>200 CLARENDON STREET, 52ND FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02116</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001618442</rptOwnerCik>
            <rptOwnerName>Cormorant Global Healthcare Master Fund, LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>200 CLARENDON STREET, 52ND FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02116</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001599214</rptOwnerCik>
            <rptOwnerName>Chen Bihua</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CORMORANT ASSET MANAGEMENT, LLC</rptOwnerStreet1>
            <rptOwnerStreet2>200 CLARENDON STREET, 52ND FLOOR</rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02116</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1988208</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Shares reported herein represent 1,658,151 shares held by Cormorant Global Healthcare Master Fund, LP (the &quot;Master Fund&quot;) and 330,057 shares held by a managed account (the &quot;Account&quot;). Cormorant Asset Management, LLC (&quot;Cormorant&quot;) serves as the investment manager of the Master Fund and the Account. Cormorant Global Healthcare GP, LLC (&quot;GP LLC&quot;) serves as General Partner of the Master Fund. Chen Bihua serves as manager of Cormorant and GP LLC. Each of the Reporting Persons disclaims beneficial ownership of the shares reported herein except to the extent of its or his pecuniary interest therein, and the filing of this Form 3 shall not be construed as an admission that any of the Reporting Persons is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934 or for any other purpose.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ CORMORANT ASSET MANAGEMENT, LLC By: Bihua Chen, Managing Member</signatureName>
        <signatureDate>2016-06-13</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ CORMORANT GLOBAL HEALTHCARE GP, LLC By: Bihua Chen, Managing Member</signatureName>
        <signatureDate>2016-06-13</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ CORMORANT GLOBAL HEALTHCARE MASTER FUND, LP By: Cormorant Global Healthcare GP, LLC, its General Partner By: Bihua Chen, Managing Member</signatureName>
        <signatureDate>2016-06-13</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Bihua Chen</signatureName>
        <signatureDate>2016-06-13</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
