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Stock Plans and Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2024

Share-Based Payment Arrangement [Abstract]

Schedule of Stock Option

A summary of stock option activity under the 2010 Plan and Inducement Awards are summarized as follows:

			Number of Options						Weighted Average Exercise Price per Share						Weighted Average Remaining Contractual Life						Aggregate Intrinsic Value (000's)
Outstanding, December 31, 2023			840,880						$	47.58					7.16						$	91
Granted			518,270						11.39
Exercised			—						—
Canceled			(198,899)						45.82
Outstanding, December 31, 2024			1,160,251						$	33.44					7.19						$	—
Exercisable at December 31, 2024			575,688						$	55.36					5.50						$	—
Vested and unvested expected to vest at December 31, 2024			1,160,251						$	33.44					7.19						$	—

Schedule of Valuation Assumptions Used to Calculate Fair Value of Employee Options Awarded

the following estimated assumptions under the Black-Scholes option pricing model:

			For the Year Ended December 31,
			2024						2023
Expected term (years)			6.0						5.5
Risk-free interest rate			3.9-4.5%						3.5-4.7%
Expected volatility			114-116%						115-116%
Expected dividend yield			None						None

Schedule of Restricted Stock Awards

The following table presents a summary of outstanding RSAs under the 2010 Plan as of December 31, 2024:

			Number of Shares						Weighted Average Grant Date Fair Value
Unvested, December 31, 2023			110,500						$	18.20
Awarded			—						—
Vested			(65,988)						18.20
Forfeited			(4,375)						18.20
Unvested, December 31, 2024			40,137						$	18.20

Schedule of Stock-Based Compensation Expense

For the years ended December 31, 2024 and 2023, the Company recorded stock-based compensation expense to the following line items in its costs and expenses section of the Consolidated Statements of Operations and Comprehensive Loss: 

			For the Year Ended December 31,
			2024						2023
Research and development expenses			$	2,760					$	2,770
General and administrative expenses			3,167						3,230
Total stock-based compensation expense			$	5,927					$	6,000

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Schedule of employee and non employee share based compensation allocation of recognized period costs.

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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