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Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details)	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Income Tax Disclosure [Abstract]
Statutory federal income tax rate	21.00%	21.00%
State income taxes, net of federal benefit	5.90%	6.10%
Research and development tax credits	4.30%	3.70%
Orphan drug tax credits	4.40%	4.90%
Expiration of NOLs/credits	(6.10%)	(6.30%)
Other	(0.30%)	1.50%
Stock based compensation	(1.70%)	(2.50%)
Change in valuation allowance	(27.50%)	(28.40%)
Effective income tax rate	0.00%	0.00%

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Effective income tax reconciliation net operating loss expirations.

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Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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