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Income Taxes - Narrative (Details) - USD ($)	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Income Taxes [Line Items]
Orphan drug tax credit carryforwards	$ 26,885,000	$ 24,983,000
Deferred tax assets, capitalization of section 174 costs	21,800,000	16,900,000
Valuation allowance	210,112,000	198,212,000
Increase in valuation allowance	11,900,000	13,500,000
Unrecognized tax benefits	0	0
Uncertain tax position	0
Federal
Income Taxes [Line Items]
Net operating loss	84,500,000
Federal | Research and Experimentation
Income Taxes [Line Items]
Research and experimentation credit carryforwards	14,000,000.0	12,900,000
Federal | Tax Years 2025 through 2038
Income Taxes [Line Items]
Net operating loss	32,100,000
State
Income Taxes [Line Items]
Net operating loss	19,600,000
State | Research and Experimentation
Income Taxes [Line Items]
Research and experimentation credit carryforwards	$ 4,200,000	$ 4,100,000

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