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  <xs:element id="cris_PaymentsOfFutureRoyaltyLiabilityNetOfImputedInterest" abstract="false" name="PaymentsOfFutureRoyaltyLiabilityNetOfImputedInterest" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_IncreaseDecreaseInAccruedExpensesAndAccountsPayableNonCashIssuanceCosts" abstract="false" name="IncreaseDecreaseInAccruedExpensesAndAccountsPayableNonCashIssuanceCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_CashEquivalentsMarketableSecuritiesAndInvestmentsPolicyPolicyTextBlock" abstract="false" name="CashEquivalentsMarketableSecuritiesAndInvestmentsPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="cris_OtherAssetsPolicyPolicyTextBlock" abstract="false" name="OtherAssetsPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="cris_FairValueMeasurementInputsAndValuationTechniqueForEquityInstrumentTableTextBlock" abstract="false" name="FairValueMeasurementInputsAndValuationTechniqueForEquityInstrumentTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="cris_ScheduleOfEmployeeAndNonEmployeeShareBasedCompensationAllocationOfRecognizedPeriodCostsTableTextBlock" abstract="false" name="ScheduleOfEmployeeAndNonEmployeeShareBasedCompensationAllocationOfRecognizedPeriodCostsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="cris_ResearchAndDevelopmentCostsCurrent" abstract="false" name="ResearchAndDevelopmentCostsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_OberlandCapitalMember" abstract="true" name="OberlandCapitalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_ProceedsFromRoyaltyPurchaseAgreement" abstract="false" name="ProceedsFromRoyaltyPurchaseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_RoyaltyPurchaseAgreementTermsPurchaserDefaultOptionPeriod" abstract="false" name="RoyaltyPurchaseAgreementTermsPurchaserDefaultOptionPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cris_PercentageOfRoyaltyPurchaseAgreement" abstract="false" name="PercentageOfRoyaltyPurchaseAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cris_RoyaltyPurchaseAgreementInterestRate" abstract="false" name="RoyaltyPurchaseAgreementInterestRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cris_RoyaltyPurchaseAgreementTransactionFeesAndClosingCosts" abstract="false" name="RoyaltyPurchaseAgreementTransactionFeesAndClosingCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_NonmonetaryTransactionRollForward" abstract="true" name="NonmonetaryTransactionRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="cris_RoyaltyPurchaseAgreementLiabilityCarryingValue" abstract="false" name="RoyaltyPurchaseAgreementLiabilityCarryingValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_RoyaltyPurchaseAgreementAccretionExpense" abstract="false" name="RoyaltyPurchaseAgreementAccretionExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_RoyaltyPurchaseAgreementIssuanceCostsCapitalizedAmortization" abstract="false" name="RoyaltyPurchaseAgreementIssuanceCostsCapitalizedAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_PaymentsOfFutureRoyaltyLiability" abstract="false" name="PaymentsOfFutureRoyaltyLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_CurrentPortionOfFutureRoyaltyLiability" abstract="false" name="CurrentPortionOfFutureRoyaltyLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_RoyaltyPurchaseAgreementLiabilityNetOfCurrentPortion" abstract="false" name="RoyaltyPurchaseAgreementLiabilityNetOfCurrentPortion" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_GenentechIncMember" abstract="true" name="GenentechIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_AurigeneDiscoveryTechnologiesLtdMember" abstract="true" name="AurigeneDiscoveryTechnologiesLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_IRAK4PD1VISTAPD1TIM3ProgramMember" abstract="true" name="IRAK4PD1VISTAPD1TIM3ProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_PercentageOfRoyaltyOnNetSales" abstract="false" name="PercentageOfRoyaltyOnNetSales" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cris_ReducedRoyaltyRate" abstract="false" name="ReducedRoyaltyRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cris_CollaborationAgreementTermsPercentageOfRoyaltyFeesReceivable" abstract="false" name="CollaborationAgreementTermsPercentageOfRoyaltyFeesReceivable" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cris_CantorFitzgeraldAndCoMember" abstract="true" name="CantorFitzgeraldAndCoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_October2024OfferingsMember" abstract="true" name="October2024OfferingsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_March2025OfferingsMember" abstract="true" name="March2025OfferingsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_RegisteredDirectOfferingMember" abstract="true" name="RegisteredDirectOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_July2025OfferingsMember" abstract="true" name="July2025OfferingsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_UnregisteredWarrantsMember" abstract="true" name="UnregisteredWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_PreFundedUnregisteredWarrantsMember" abstract="true" name="PreFundedUnregisteredWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_SaleOfStockAuthorizedMaximumAmount" abstract="false" name="SaleOfStockAuthorizedMaximumAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_StockSaleAgreementCompensationFeePercentageOfGrossProceeds" abstract="false" name="StockSaleAgreementCompensationFeePercentageOfGrossProceeds" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cris_StockSaleAgreementRemainingAuthorizedAmount" abstract="false" name="StockSaleAgreementRemainingAuthorizedAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_StockSaleAgreementSaleRestrictionMaximumPublicFloat" abstract="false" name="StockSaleAgreementSaleRestrictionMaximumPublicFloat" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_SaleOfStockAgreementMaximumPercentageOfPublicFloat" abstract="false" name="SaleOfStockAgreementMaximumPercentageOfPublicFloat" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cris_StockSaleAgreementSaleRestrictionPeriod" abstract="false" name="StockSaleAgreementSaleRestrictionPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cris_ClassOfWarrantOrRightExpirationPeriod" abstract="false" name="ClassOfWarrantOrRightExpirationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cris_PurchasePriceShare" abstract="false" name="PurchasePriceShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cris_SaleOfEquityPricePerShare" abstract="false" name="SaleOfEquityPricePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="cris_SaleOfEquityConsiderationReceivedOnTransaction" abstract="false" name="SaleOfEquityConsiderationReceivedOnTransaction" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_StockIssuedDuringPeriodCommonStockFairValue" abstract="false" name="StockIssuedDuringPeriodCommonStockFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_ClassOfWarrantOrRightPurchasePrice" abstract="false" name="ClassOfWarrantOrRightPurchasePrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="cris_StockOptionsorStockAppreciationRightsMember" abstract="true" name="StockOptionsorStockAppreciationRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_RestrictedStockRSUsOtherStockBasedAwardsOrPerformanceAwardsMember" abstract="true" name="RestrictedStockRSUsOtherStockBasedAwardsOrPerformanceAwardsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_AmendedAndRestatedTwoThousandTenStockIncentivePlanMember" abstract="true" name="AmendedAndRestatedTwoThousandTenStockIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_TwoThousandAndTenPlanMember" abstract="true" name="TwoThousandAndTenPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_EmployeeStockPurchasePlanMember" abstract="true" name="EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_NonEmployeeDirectorsMember" abstract="true" name="NonEmployeeDirectorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_ShareBasedCompensationPlans" abstract="false" name="ShareBasedCompensationPlans" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cris_CommonStockAdditionalCapitalSharesReservedForFutureIssuance" abstract="false" name="CommonStockAdditionalCapitalSharesReservedForFutureIssuance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cris_SharebasedCompensationArrangementBySharebasedPaymentAwardSharesRemovedFromAvailableSharePoolPerShare" abstract="false" name="SharebasedCompensationArrangementBySharebasedPaymentAwardSharesRemovedFromAvailableSharePoolPerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="cris_NumberOfSharesAwardedUnderStockValueLessThanSpecificPercentageOfFairMarketValue" abstract="false" name="NumberOfSharesAwardedUnderStockValueLessThanSpecificPercentageOfFairMarketValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cris_EmployeeStockPurchasePlanEnrollmentPeriod" abstract="false" name="EmployeeStockPurchasePlanEnrollmentPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cris_NumberOfPurchasePeriodsPerEnrollmentPeriod" abstract="false" name="NumberOfPurchasePeriodsPerEnrollmentPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cris_SharebasedCompensationArrangementBySharebasedPaymentAwardStockPlanOfferingPeriod" abstract="false" name="SharebasedCompensationArrangementBySharebasedPaymentAwardStockPlanOfferingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cris_StockAvailableForFuturePurchaseUnderEmployeeStockPurchasePlans" abstract="false" name="StockAvailableForFuturePurchaseUnderEmployeeStockPurchasePlans" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cris_October2024CommonWarrantsMember" abstract="true" name="October2024CommonWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_March2025CommonWarrantsMember" abstract="true" name="March2025CommonWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_ResearchAndDevelopmentEmployeeRelatedCosts" abstract="false" name="ResearchAndDevelopmentEmployeeRelatedCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_GeneralAndAdministrativeEmployeeRelatedCosts" abstract="false" name="GeneralAndAdministrativeEmployeeRelatedCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
