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Stock Plans and Stock-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2025

Share-Based Payment Arrangement [Abstract]

Schedule of Stock Option

A summary of stock option activity under the 2010 Plan and Inducement Awards are summarized as follows:

			Number of Shares						Weighted Average Exercise Price per Share						Weighted Average Remaining Contractual Life						Aggregate Intrinsic Value
Outstanding, December 31, 2024			1,160,251						$	33.44					7.19						$	—
Granted			1,388,400						3.04
Exercised			—						—
Canceled/Forfeited			(122,121)						10.57
Outstanding, June 30, 2025			2,426,530						$	17.30					8.17						$	—
Exercisable at June 30, 2025			774,125						$	45.01					5.64						$	—
Vested and unvested expected to vest at June 30, 2025			2,426,530						$	17.30					8.17						$	—

Schedule of Valuation Assumptions Used to Calculate Fair Value of Employee Options Awarded

the following estimated assumptions under the Black-Scholes option pricing model:

			Six Months Ended June 30,
			2025						2024
Expected term (years)			6.0						6.0
Risk free interest rate			3.9% - 4.4%						3.9% - 4.3%
Expected volatility			113% - 114%						114% - 116%
Expected dividends			None						None

Schedule of Restricted Stock Awards

The following table presents a summary of RSAs under the 2010 Plan as of June 30, 2025:

			Number of Shares						Weighted Average Grant Date Fair Value
Unvested, December 31, 2024			40,137						$	18.20
Awarded			—						—
Vested			(39,637)						18.20
Forfeited			(500)						18.20
Unvested, June 30, 2025			—						$	—

The following table presents a summary of RSUs under the 2010 Plan as of June 30, 2025:

			Number of Shares						Weighted Average Grant Date Fair Value
Unvested, December 31, 2024			—						$	—
Awarded			350,600						3.13
Vested			—						—
Forfeited			(67,100)						3.13
Unvested, June 30, 2025			283,500						3.13

Schedule of Stock-Based Compensation Expense

For the three and six months ended June 30, 2025 and 2024, the Company recorded stock-based compensation expense to the following line items in its costs and expenses section of the Condensed Consolidated Statements of Operations and Comprehensive Loss:

			Three Months Ended June 30,												Six Months Ended June 30,
(in thousands)			2025						2024						2025						2024
Research and development			$	492					$	737					$	1,084					$	1,546
General and administrative			643						967						1,215						1,717
Total stock-based compensation expense			$	1,135					$	1,704					$	2,299					$	3,263

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Schedule Of Employee And Non Employee Share Based Compensation Allocation Of Recognized Period Costs

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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