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Stock Plans and Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2025

Share-Based Payment Arrangement [Abstract]

Schedule of Stock Option

A summary of stock option activity under the 2010 Plan and Inducement Awards are summarized as follows:

			Number of Shares						Weighted Average Exercise Price per Share						Weighted Average Remaining Contractual Life						Aggregate Intrinsic Value
Outstanding, December 31, 2024			1,160,251						$	33.44					7.19						$	—
Granted			1,388,400						3.04
Exercised			—						—
Canceled/Forfeited			(178,825)						14.17
Outstanding, September 30, 2025			2,369,826						$	17.19					7.94						$	—
Exercisable at September 30, 2025			795,029						$	43.64					5.55						$	—
Vested and unvested expected to vest at September 30, 2025			2,369,826						$	17.19					7.94						$	—

Schedule of Valuation Assumptions Used to Calculate Fair Value of Employee Options Awarded

the following estimated assumptions under the Black-Scholes option pricing model:

			Nine Months Ended September 30,
			2025						2024
Expected term (years)			6.0						6.0
Risk free interest rate			3.9% - 4.4%						3.9% - 4.5%
Expected volatility			113% - 114%						114% - 116%
Expected dividends			None						None

Schedule of Restricted Stock Awards

The following table presents a summary of RSAs under the 2010 Plan as of September 30, 2025:

			Number of Shares						Weighted Average Grant Date Fair Value
Unvested, December 31, 2024			40,137						$	18.20
Awarded			—						—
Vested			(39,637)						18.20
Forfeited			(500)						18.20
Unvested, September 30, 2025			—						$	—

The following table presents a summary of RSUs under the 2010 Plan as of September 30, 2025:

			Number of Shares						Weighted Average Grant Date Fair Value
Unvested, December 31, 2024			—						$	—
Awarded			350,600						3.13
Vested			—
Forfeited			(87,200)						3.13
Unvested, September 30, 2025			263,400						3.13

Schedule of Stock-Based Compensation Expense

For the three and nine months ended September 30, 2025 and 2024, the Company recorded stock-based compensation expense to the following line items in its costs and expenses section of the Condensed Consolidated Statements of Operations and Comprehensive Loss:

			Three Months Ended September 30,												Nine Months Ended September 30,
(in thousands)			2025						2024						2025						2024
Research and development			$	368					$	624					$	1,452					$	2,168
General and administrative			556						760						1,771						2,479
Total stock-based compensation expense			$	924					$	1,384					$	3,223					$	4,647

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Schedule Of Employee And Non Employee Share Based Compensation Allocation Of Recognized Period Costs

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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