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Stock Plans and Stock-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2026

Share-Based Payment Arrangement [Abstract]

Schedule of Stock Option

A summary of stock option activity under the 2026 Plan, 2010 Plan, and Inducement Awards are summarized as follows:

			Number of Shares						Weighted Average Exercise Price per Share						Weighted Average Remaining Contractual Life						Aggregate Intrinsic Value
Outstanding, December 31, 2025			2,429,064						$	16.59					7.80						$	—
Granted			—						—
Exercised			—						—
Canceled/Forfeited			(101,599)						37.64
Outstanding, March 31, 2026			2,327,465						$	15.67					7.40						$	—
Exercisable at March 31, 2026			1,164,823						$	28.71					6.02						$	—
Vested and unvested expected to vest at March 31, 2026			2,327,465						$	15.67					7.40						$	—

Schedule of Valuation Assumptions Used to Calculate Fair Value of Employee Options Awarded

The weighted average grant date fair value of the stock options granted during the three months ended March 31, 2025 was $2.67 and was calculated using the following estimated assumptions under the Black-Scholes option pricing model:

									Three Months Ended March 31,
									2025
Expected term (years)									6.0
Risk free interest rate									4.4%
Expected volatility									113%
Expected dividends									None

Schedule of Restricted Stock Awards

The following table presents a summary of RSUs under the 2010 Plan as of March 31, 2026:

			Number of Shares						Weighted Average Grant Date Fair Value
Unvested, December 31, 2025			257,400						$	3.13
Awarded			—						—
Vested			(64,350)						3.13
Forfeited			(44,700)						3.13
Unvested, March 31, 2026			148,350						$	3.13

Schedule of Stock-Based Compensation Expense

For the three months ended March 31, 2026 and 2025, the Company recorded stock-based compensation expense to the following line items in its costs and expenses section of the Condensed Consolidated Statements of Operations and Comprehensive Loss:

			Three Months Ended March 31,
(in thousands)			2026						2025
Research and development			$	229					$	592
General and administrative			346						572
Total stock-based compensation expense			$	575					$	1,164

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Schedule Of Employee And Non Employee Share Based Compensation Allocation Of Recognized Period Costs

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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-Name Accounting Standards Codification
-Section 50
-Subparagraph (c)
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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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