-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 GyINLv0wNO1/3AbNW+9xcZTafZNLEGVDrOOJAWF6yUNqyORuYZh12k8xt6dO6AY1
 mTt1DcOb+M/jysQGuq1i7g==

<SEC-DOCUMENT>0000929638-09-000486.txt : 20090316
<SEC-HEADER>0000929638-09-000486.hdr.sgml : 20090316
<ACCEPTANCE-DATETIME>20090316181256
ACCESSION NUMBER:		0000929638-09-000486
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20090312
FILED AS OF DATE:		20090316
DATE AS OF CHANGE:		20090316

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Nelson Kerry
		CENTRAL INDEX KEY:			0001332636

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33957
		FILM NUMBER:		09685845

	MAIL ADDRESS:	
		STREET 1:		C/O SKYSTONE CAPITAL MANAGEMENT LP
		STREET 2:		TWO INTERNATIONAL PLACE, SUITE 1800
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HARVARD BIOSCIENCE INC
		CENTRAL INDEX KEY:			0001123494
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		IRS NUMBER:				043306140
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		84 OCTOBER HILL RD
		CITY:			HOLLISTON
		STATE:			MA
		ZIP:			01746
		BUSINESS PHONE:		5088938999

	MAIL ADDRESS:	
		STREET 1:		84 OCTOBER HILL ROAD
		CITY:			HOLLISTON
		STATE:			MA
		ZIP:			01746

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Skystone Advisors LLC
		CENTRAL INDEX KEY:			0001332634
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33957
		FILM NUMBER:		09685846

	BUSINESS ADDRESS:	
		STREET 1:		TWO INTERNATIONAL PLACE
		STREET 2:		SUITE 1800
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		617-603-2085

	MAIL ADDRESS:	
		STREET 1:		TWO INTERNATIONAL PLACE
		STREET 2:		SUITE 1800
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>frm4_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2009-03-12</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001123494</issuerCik>
        <issuerName>HARVARD BIOSCIENCE INC</issuerName>
        <issuerTradingSymbol>HBIO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001332634</rptOwnerCik>
            <rptOwnerName>Skystone Advisors LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>TWO INTERNATIONAL PLACE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1800</rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02110</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001332636</rptOwnerCik>
            <rptOwnerName>Nelson Kerry</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O SKYSTONE CAPITAL MANAGEMENT LP</rptOwnerStreet1>
            <rptOwnerStreet2>TWO INTERNATIONAL PLACE, SUITE 1800</rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02110</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-03-12</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>7958</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>2.75</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3751979</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Shares reported herein represent shares held by HSO Limited Partnership and HSE Master Fund Limited Partnership.  Skystone
 Advisors LLC is the investment member of the general partner of HSO Limited Partnership and the general partner of HSE
 Master Fund Limited Partnership.  Ms. Nelson is the managing member of Skystone Advisors LLC.  Each of Ms. Nelson and
 Skystone Advisors LLC disclaims beneficial ownership of the shares reported herein, except to the extent of its or her
 pecuniary interest therein, and the inclusion of the shares reported herein shall not be deemed an admission of beneficial
 ownership of such shares for purposes of Section 16 or for any other purpose.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/Skystone Advisors LLC, by Kerry Nelson, Managing Member</signatureName>
        <signatureDate>2009-03-16</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/Kerry Nelson</signatureName>
        <signatureDate>2009-03-16</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----
