<SEC-DOCUMENT>0001171843-19-003707.txt : 20190530
<SEC-HEADER>0001171843-19-003707.hdr.sgml : 20190530
<ACCEPTANCE-DATETIME>20190530161637
ACCESSION NUMBER:		0001171843-19-003707
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20190530
DATE AS OF CHANGE:		20190530
EFFECTIVENESS DATE:		20190530

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HARVARD BIOSCIENCE INC
		CENTRAL INDEX KEY:			0001123494
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		IRS NUMBER:				043306140
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-231825
		FILM NUMBER:		19866762

	BUSINESS ADDRESS:	
		STREET 1:		84 OCTOBER HILL RD
		CITY:			HOLLISTON
		STATE:			MA
		ZIP:			01746
		BUSINESS PHONE:		5088938999

	MAIL ADDRESS:	
		STREET 1:		84 OCTOBER HILL ROAD
		CITY:			HOLLISTON
		STATE:			MA
		ZIP:			01746
</SEC-HEADER>
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<TYPE>S-8
<SEQUENCE>1
<FILENAME>fs8_053019.htm
<DESCRIPTION>FORM S-8
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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>As filed with the Securities and Exchange Commission on May 30,
2019</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: right; margin: 0pt 0"><B>Registration No. 333-<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U></B></P>

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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>UNITED STATES</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>WASHINGTON, D.C.&nbsp;20549</B></P>

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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>FORM&nbsp;S-8</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</B></P>

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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>HARVARD BIOSCIENCE, INC.</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>(Exact Name of Registrant as Specified in Its Charter)</B></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="vertical-align: bottom; width: 45%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
    <TD STYLE="vertical-align: top; width: 10%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 45%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>04-3306140</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>(State of Incorporation)</B></FONT></TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>(I.R.S. Employer</B></P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Identification No.)</B></P></TD></TR>
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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 45%">
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>84&nbsp;October Hill Road</B></P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Holliston, Massachusetts</B></P></TD>
    <TD STYLE="width: 10%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 45%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>01746</B></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>(Address of Principal Executive Offices)</B></FONT></TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>(Zip Code)</B></FONT></TD></TR>
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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>HARVARD BIOSCIENCE, INC. </B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>EMPLOYEE STOCK PURCHASE PLAN</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>(Full Title of the Plan)</B></P>

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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Jeffrey A. Duchemin, Chief Executive Officer</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>HARVARD BIOSCIENCE, INC.</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>84&nbsp;October Hill Road</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Holliston, Massachusetts 01746</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>(508) 893-8999</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>(Name, address, and telephone number, including area code, of
agent for service)</B></P>

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    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B><I>With copies to:</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Chad J. Porter</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Burns&nbsp;&amp; Levinson LLP</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>125 Summer Street</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Boston, Massachusetts 02110</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>(617) 345-3000 </B></P>

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    <TD STYLE="width: 100%; border-bottom: black 1pt solid; font-size: 10pt">&nbsp;</TD></TR>
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    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
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<P STYLE="font-size: 10pt; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated
filer, a non-accelerated filer, or a smaller reporting company. See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated
filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule&nbsp;12b-2 of the Exchange Act.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

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<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="2" STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Large&nbsp;accelerated&nbsp;filer</FONT></TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Accelerated&nbsp;filer</FONT></TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">x</FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="2" STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Non-accelerated filer</FONT></TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;(Do not check if a smaller reporting company)</FONT></TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Smaller&nbsp;reporting&nbsp;company</FONT></TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">x</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Emerging growth company</FONT></TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD></TR>
<TR>
    <TD STYLE="width: 18%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 23%">&nbsp;</TD>
    <TD STYLE="width: 8%">&nbsp;</TD></TR>
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<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">If an emerging growth company, indicate by check mark if the registrant has elected not
to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
Section 7(a)(2)(B) of the Securities Act <FONT STYLE="font-family: Wingdings">&uml;</FONT></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Calculation of Registration Fee</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 36%; border-top: black 2.25pt double; border-bottom: black 1pt solid">
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Title of Securities</B></P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>to be Registered</B></P></TD>
    <TD STYLE="width: 1%; border-top: black 2.25pt double; border-bottom: black 1pt solid; border-left: black 1pt solid">&nbsp;</TD>
    <TD STYLE="width: 15%; border-top: black 2.25pt double; border-bottom: black 1pt solid">
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Amount</B></P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>to be</B></P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Registered(1)</B></P></TD>
    <TD STYLE="width: 1%; border-top: black 2.25pt double; border-bottom: black 1pt solid; border-left: black 1pt solid">&nbsp;</TD>
    <TD STYLE="width: 15%; border-top: black 2.25pt double; border-bottom: black 1pt solid">
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Proposed</B></P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Maximum</B></P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Offering Price</B></P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Per Share(2)</B></P></TD>
    <TD STYLE="width: 1%; border-top: black 2.25pt double; border-bottom: black 1pt solid; border-left: black 1pt solid">&nbsp;</TD>
    <TD STYLE="width: 15%; border-top: black 2.25pt double; border-bottom: black 1pt solid">
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Proposed</B></P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Maximum</B></P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Aggregate</B></P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Offering&nbsp;Price(2)</B></P></TD>
    <TD STYLE="width: 1%; border-top: black 2.25pt double; border-bottom: black 1pt solid; border-left: black 1pt solid">&nbsp;</TD>
    <TD STYLE="width: 15%; border-top: black 2.25pt double; border-bottom: black 1pt solid">
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Amount of</B></P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Registration&nbsp;Fee</B></P></TD></TR>
<TR STYLE="background-color: #CCEEFF">
    <TD STYLE="vertical-align: top; border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt">Common Stock, par value $0.01 per share</FONT></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 2.25pt double; border-left: black 1pt solid">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 2.25pt double; text-align: center"><FONT STYLE="font-size: 10pt">350,000&nbsp;shares</FONT></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 2.25pt double; border-left: black 1pt solid">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 2.25pt double; text-align: center"><FONT STYLE="font-size: 10pt">$2.31</FONT></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 2.25pt double; border-left: black 1pt solid">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 2.25pt double; text-align: center"><FONT STYLE="font-size: 10pt">$808,500</FONT></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 2.25pt double; border-left: black 1pt solid">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 2.25pt double; text-align: center"><FONT STYLE="font-size: 10pt">$98.00</FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 2%"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
    <TD STYLE="width: 98%"><FONT STYLE="font-size: 10pt">This Registration Statement relates to 350,000 shares of Common Stock, par value $0.01 per share, of Harvard Bioscience, Inc. (&ldquo;Common Stock&rdquo;) available for issuance under the Harvard Bioscience, Inc. Employee Stock Purchase Plan (as amended, the &ldquo;ESPP&rdquo;);&nbsp;plus such indeterminate number of additional shares of Common Stock as may be required pursuant to the ESPP in the event of a stock dividend, stock split, split-up, recapitalization or other similar event. </FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 2%"><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
    <TD STYLE="width: 98%"><FONT STYLE="font-size: 10pt">This estimate is made pursuant to Rule 457(c) and (h)&nbsp;under the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), solely for the purpose of determining the amount of the registration fee. The registration fee is based upon the average of the high and low sales prices for a share of Common Stock on May 24, 2019, as reported on the NASDAQ Global Market.</FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>







<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: right; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>INCORPORATION BY REFERENCE OF PRIOR REGISTRATION STATEMENT</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 24.5pt; margin: 0pt 0">This Registration Statement is filed by Harvard Bioscience, Inc.
(the &ldquo;Registrant&rdquo;) for the purpose of registering pursuant to General Instruction E to Form S-8, 350,000 additional
shares of the Registrant&rsquo;s common stock, $0.01 par value per share (the &ldquo;Common Stock&rdquo;) under Amendment No.&nbsp;4
to Harvard Bioscience, Inc. Employee Stock Purchase Plan (the &ldquo;ESPP&rdquo;). On April&nbsp;5, 2019, the Registrant filed
with the Securities and Exchange Commission (the &ldquo;Commission&rdquo;) a definitive proxy statement that included proposals
to, among other things, increase the number of shares available for issuance under the ESPP by 350,000 shares of Common Stock.
The proposal to increase the number of shares available for issuance under the ESPP was approved by the Registrant&rsquo;s stockholders
on May&nbsp;16, 2019. This Registration Statement registers the 350,000 additional shares of Common Stock available for issuance
under the ESPP.</P>

<P STYLE="font-size: 10pt; text-indent: 24.5pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 24.5pt; margin: 0pt 0">The additional 350,000 shares of Common Stock available for issuance
under the ESPP registered pursuant to this Registration Statement are the same class as those included on registration statements
on Form S-8, and post-effective amendments thereto, filed on January&nbsp;17, 2001 (File No.&nbsp;333-53848), June&nbsp;15, 2001
(File No.&nbsp;333-53848), June 7, 2013 (File No.&nbsp;333-189175) and June 5, 2017 (File No. 333-218497). The contents of all
aforementioned Registration Statements, including any amendments thereto or filings incorporated therein, are incorporated herein
by reference, except as modified herein.</P>

<P STYLE="font-size: 10pt; text-indent: 27pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>PART II</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 60px"><FONT STYLE="font-size: 10pt"><B>Item 3.</B></FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><B> Incorporation of Documents by Reference. </B></FONT></TD></TR>
</TABLE>

<P STYLE="font-size: 10pt; margin: 0pt 0 0pt 24.45pt">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0 0pt 24.45pt"></P>

<P STYLE="font-size: 10pt; text-indent: 24.5pt; margin: 0pt 0">The Registrant is subject to the informational and reporting requirements
of Sections 13(a), 14 and 15(d) of the Securities Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;), and in accordance
therewith files reports, proxy statements and other information with the Commission. The following documents, which are on file
with the Commission, are incorporated in this registration statement by reference:</P>

<P STYLE="font-size: 10pt; text-indent: 24.5pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 24.5pt; margin: 0pt 0">(a) The Registrant&rsquo;s Annual Report on Form 10-K for the year
ended December&nbsp;31, 2018, filed with the Commission on March&nbsp;18, 2019;</P>

<P STYLE="font-size: 10pt; text-indent: 24.5pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 24.5pt; margin: 0pt 0">(b) All other reports filed by the Registrant pursuant to Section&nbsp;13(a)
or 15(d) of the Exchange Act, since the end of the fiscal year covered by the Registrant&rsquo;s Annual Report on Form 10-K described
in (a)&nbsp;above; and</P>

<P STYLE="font-size: 10pt; text-indent: 24.5pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 24.5pt; margin: 0pt 0">(c) The description of the Registrant&rsquo;s Common Stock contained
in the Registrant&rsquo;s registration statement on Form 8-A (File No. 000-31923&nbsp;) filed with the Commission on November&nbsp;9,
2000 under the Exchange Act, including any amendment or report filed for the purpose of updating such description.</P>

<P STYLE="font-size: 10pt; text-indent: 24.5pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 24.5pt; margin: 0pt 0">All documents subsequently filed by the registrant pursuant to Sections
13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment which indicates that all securities
offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by
reference in this Registration Statement and to be part hereof from the date of the filing of such documents. Any statement contained
in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for the
purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document
which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any statement so modified
or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</P>

<P STYLE="font-size: 10pt; text-indent: 24.5pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 60px"><FONT STYLE="font-size: 10pt"><B>Item 8.</B></FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><B>Exhibits</B></FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-indent: 45pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 45pt; margin: 0pt 0">The Exhibit Index immediately preceding the exhibits is incorporated
herein by reference.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>SIGNATURES</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 27pt; margin: 0pt 0">Pursuant to the requirements of the Securities Act of 1933, the Company
certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused
this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Holliston, Massachusetts,
on this 30<SUP>th</SUP> day of May, 2019.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="4"><FONT STYLE="font-size: 10pt">HARVARD BIOSCIENCE, INC.</FONT></TD></TR>
<TR>
    <TD STYLE="width: 52%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 26%">&nbsp;</TD>
    <TD STYLE="width: 18%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ JEFFREY A. DUCHEMIN</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="3"><FONT STYLE="font-size: 10pt">Jeffrey A. Duchemin, <I>Chief Executive Officer</I></FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B><A NAME="a_001"></A>POWER OF ATTORNEY</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 27pt; margin: 0pt 0">KNOW ALL BY THESE PRESENTS that each individual whose signature appears
below constitutes and appoints each of Jeffrey A. Duchemin and Kamalam Unninayar as such person&rsquo;s true and lawful attorney-in-fact
and agent with full power of substitution and resubstitution, for such person in such person&rsquo;s name, place and stead, in
any and all capacities, to sign any and all amendments (including post-effective amendments) to this registration statement (or
any registration statement for the same offering that is to be effective upon filing pursuant to Rule 462(b) under the Securities
Act of 1933), and to file the same, with all exhibits thereto, and all documents in connection therewith, with the Securities and
Exchange Commission, granting unto each said attorney-in-fact and agent full power and authority to do and perform each and every
act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as such person
might or could do in person, hereby ratifying and confirming all that any said attorney-in-fact and agent, or any substitute or
substitutes of any of them, may lawfully do or cause to be done by virtue hereof.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 27pt; margin: 0pt 0">Pursuant to the requirements of the Securities Act of 1933, this registration
statement has been signed by the following persons in the capacities and on the date indicated. Each person listed below has signed
this registration statement as an officer or director of Harvard Bioscience, Inc.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 30%; text-align: center"><FONT STYLE="font-size: 10pt"><B>Signature</B></FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 48%; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title</B></FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 20%; text-align: center"><FONT STYLE="font-size: 10pt"><B>Date</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ JEFFREY A. DUCHEMIN</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Director and Chief Executive Officer</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 30, 2019</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">Jeffrey A. Duchemin</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">(Principal Executive Officer)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ KAMALAM UNNINAYAR</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Chief Financial Officer</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 30, 2019</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">Kamalam Unninayar</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">(Principal Financial Officer and Principal Accounting Officer)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ JAMES GREEN</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 30, 2019</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">James Green</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ JOHN F. KENNEDY</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 30, 2019</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">John F. Kennedy</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ KATHERINE A. EADE</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 30, 2019</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">Katherine A. Eade</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ BERTRAND LOY</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 30, 2019</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">Bertrand Loy</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ THOMAS W. LOEWALD</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 30, 2019</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">Thomas W. Loewald</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>EXHIBIT INDEX</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid">
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Exhibit</B></P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Number</B></P></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">
        <P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Description</B></P></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 6%; text-align: right"><A HREF="http://www.sec.gov/Archives/edgar/data/1123494/000091205700047957/a2029062zex-3_2.txt"><FONT STYLE="font-size: 10pt">(1)3.1</FONT></A></TD>
    <TD STYLE="vertical-align: top; width: 3%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 90%"><A HREF="http://www.sec.gov/Archives/edgar/data/1123494/000091205700047957/a2029062zex-3_2.txt"><FONT STYLE="font-size: 10pt">Second Amended and Restated Certificate of Incorporation of Harvard Bioscience, Inc.</FONT></A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right"><A HREF="http://www.sec.gov/Archives/edgar/data/1123494/000091205700047957/a2029062zex-3_3.txt"><FONT STYLE="font-size: 10pt">(1)3.2</FONT></A></TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1123494/000091205700047957/a2029062zex-3_3.txt"><FONT STYLE="font-size: 10pt">Amended and Restated Bylaws of Harvard Bioscience, Inc.</FONT></A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right"><A HREF="http://www.sec.gov/Archives/edgar/data/1123494/000119312507232564/dex31.htm"><FONT STYLE="font-size: 10pt">(2)3.3</FONT></A></TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1123494/000119312507232564/dex31.htm"><FONT STYLE="font-size: 10pt">Amendment No. 1 to Amended and Restated Bylaws of Harvard Bioscience, Inc. (as adopted October 30, 2007)</FONT></A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right"><A HREF="http://www.sec.gov/Archives/edgar/data/1123494/000091205700047957/a2029062zex-4_1.txt"><FONT STYLE="font-size: 10pt">(1)4.1</FONT></A></TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1123494/000091205700047957/a2029062zex-4_1.txt"><FONT STYLE="font-size: 10pt">Specimen certificate for shares of Common Stock, $0.01 par value, of Harvard Bioscience, Inc.</FONT></A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right"><A HREF="http://www.sec.gov/Archives/edgar/data/1123494/000091205700045901/a2028300zex-4_2.txt"><FONT STYLE="font-size: 10pt">(3)4.2</FONT></A></TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1123494/000091205700045901/a2028300zex-4_2.txt"><FONT STYLE="font-size: 10pt">Amended and Restated Securityholders&rsquo; Agreement dated as of March 2, 1999 by and among Harvard Apparatus, Inc., Pioneer Partnership II, Pioneer Capital Corp., First New England Capital, L.P. and Citizens Capital, Inc. and Chane Graziano and David Green</FONT></A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right"><A HREF="http://www.sec.gov/Archives/edgar/data/1123494/000091205700047957/a2029062zex-10_3.txt"><FONT STYLE="font-size: 10pt">(4)4.3</FONT></A></TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1123494/000091205700047957/a2029062zex-10_3.txt"><FONT STYLE="font-size: 10pt">Harvard Bioscience, Inc. Employee Stock Purchase Plan, as amended</FONT></A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right"><A HREF="exh_51.htm"><FONT STYLE="font-size: 10pt">*5.1</FONT></A></TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="exh_51.htm"><FONT STYLE="font-size: 10pt">Legal opinion from Burns &amp; Levinson LLP</FONT></A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right"><A HREF="exh_231.htm"><FONT STYLE="font-size: 10pt">*23.1</FONT></A></TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="exh_231.htm"><FONT STYLE="font-size: 10pt">Consent of Grant Thornton LLP, as independent registered public accounting firm</FONT></A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right"><A HREF="exh_51.htm"><FONT STYLE="font-size: 10pt">23.2</FONT></A></TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="exh_51.htm"><FONT STYLE="font-size: 10pt">Consent of Burns &amp; Levinson LLP (contained in the opinion filed as Exhibit 5.1 to this Registration Statement)</FONT></A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: right"><A HREF="#a_001"><FONT STYLE="font-size: 10pt">24.1</FONT></A></TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="#a_001"><FONT STYLE="font-size: 10pt">Power of attorney (included on the signature page to this Registration Statement)</FONT></A></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%; text-align: center"><FONT STYLE="font-size: 10pt">*</FONT></TD>
    <TD STYLE="width: 97%"><FONT STYLE="font-size: 10pt">Filed herewith.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Previously filed as an exhibit to the Company&rsquo;s Registration Statement on Form&nbsp;S-1/A (File&nbsp;No.&nbsp;333-45996) (filed on November 9, 2000) and incorporated by reference thereto.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Previously filed as an exhibit to the Company&rsquo;s Current Report on Form 8-K (filed on November&nbsp;1, 2007) and incorporated by reference thereto.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(3)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Previously filed as an exhibit to the Company&rsquo;s Registration Statement on Form&nbsp;S-1/A (File&nbsp;No.&nbsp;333-45996) (filed on October 25, 2000) and incorporated by reference thereto.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(4)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Previously filed as Appendix A to the Company&rsquo;s Definitive Schedule&nbsp;14A (Proxy Statement) (filed on April&nbsp;5, 2019) and incorporated by reference thereto.</FONT></TD></TR>
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<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>exh_51.htm
<DESCRIPTION>EXHIBIT 5.1
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<P STYLE="font-size: 10pt; text-align: right; margin: 0pt 0"><B>EXHIBIT 5.1</B></P>

<P STYLE="font-size: 10pt; text-align: right; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">May 30, 2019</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">Harvard Bioscience, Inc.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">84&nbsp;October Hill Road</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">Holliston, MA 01746-1371</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">Re: <U>Securities Being Registered under Registration Statement on Form S-8</U></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">Ladies and Gentlemen:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">This opinion letter is furnished to you in connection with your filing of a Registration
Statement on Form S-8 (the &ldquo;Registration Statement&rdquo;) pursuant to the Securities Act of 1933, as amended (the &ldquo;Securities
Act&rdquo;), on or about the date hereof relating to an aggregate of 350,000 shares (the &ldquo;Shares&rdquo;) of Common Stock,
$0.01 par value per share (the &ldquo;Common Stock&rdquo;), of Harvard Bioscience, Inc., a Delaware corporation (the &ldquo;Company&rdquo;),
that may be issued pursuant to the Company&rsquo;s Employee Stock Purchase Plan, as amended (the &ldquo;Plan&rdquo;).</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">We have reviewed such documents and made such examination of law as we have deemed appropriate
to give the opinion expressed below. We have relied, without independent verification, as to matters of fact material to the opinion
set forth below, on certificates of officers of the Company.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">The opinion expressed below is limited to the Delaware General Corporation Law (which
includes applicable provisions of the Delaware Constitution and reported judicial decisions interpreting the Delaware General Corporation
Law and the Delaware Constitution).</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">For purposes of the opinion expressed below, we have assumed that a sufficient number
of authorized but unissued shares of the Company&rsquo;s Common Stock will be available for issuance when the Shares are issued.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">Based on the foregoing, we are of the opinion that (i) the Shares have been duly authorized
and, upon issuance and delivery against payment therefor in accordance with the terms of the Plan, will be validly issued, fully
paid and nonassessable.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">We hereby consent to the inclusion of this opinion as Exhibit 5.1 to the Registration
Statement. In giving our consent, we do not admit that we are in the category of persons whose consent is required under Section&nbsp;7
of the Securities Act or the rules and regulations thereunder.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">Very truly yours,</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">BURNS&nbsp;&amp; LEVINSON LLP</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><U>/s/ BURNS&nbsp;&amp; LEVINSON LLP </U></P>

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<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>exh_231.htm
<DESCRIPTION>EXHIBIT 23.1
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<P STYLE="font-size: 10pt; text-align: right; margin: 0pt 0"><B>EXHIBIT 23.1</B></P>

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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Consent of Independent Registered Public Accounting Firm</B></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">We have issued our reports dated March 18, 2019, with respect to the consolidated financial
statements and internal control over financial reporting of Harvard Bioscience, Inc. included in the Annual Report on Form 10-K
for the year ended December 31, 2018, which are incorporated by reference in this Registration Statement. &nbsp;We consent to the
incorporation by reference of the aforementioned reports in this Registration Statement.&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">/s/ GRANT THORNTON LLP</P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">Boston, Massachusetts</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">May 30, 2019</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>



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