<SEC-DOCUMENT>0001104659-25-048458.txt : 20250514
<SEC-HEADER>0001104659-25-048458.hdr.sgml : 20250514
<ACCEPTANCE-DATETIME>20250514154959
ACCESSION NUMBER:		0001104659-25-048458
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20250512
FILED AS OF DATE:		20250514
DATE AS OF CHANGE:		20250514

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Frost Mark T
		CENTRAL INDEX KEY:			0001310262
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33957
		FILM NUMBER:		25944986

	MAIL ADDRESS:	
		STREET 1:		21 CORPORATE CIRCLE
		STREET 2:		PO BOX 15098
		CITY:			ALBANY
		STATE:			NY
		ZIP:			12033-5098

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HARVARD BIOSCIENCE INC
		CENTRAL INDEX KEY:			0001123494
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				043306140
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		84 OCTOBER HILL RD
		CITY:			HOLLISTON
		STATE:			MA
		ZIP:			01746
		BUSINESS PHONE:		5088938999

	MAIL ADDRESS:	
		STREET 1:		84 OCTOBER HILL ROAD
		CITY:			HOLLISTON
		STATE:			MA
		ZIP:			01746
</SEC-HEADER>
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<TYPE>3
<SEQUENCE>1
<FILENAME>tm2514961-1_3seq1.xml
<DESCRIPTION>OWNERSHIP DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2025-05-12</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001123494</issuerCik>
        <issuerName>HARVARD BIOSCIENCE INC</issuerName>
        <issuerTradingSymbol>HBIO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001310262</rptOwnerCik>
            <rptOwnerName>Frost Mark T</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O HARVARD BIOSCIENCE, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>84 OCTOBER HILL ROAD</rptOwnerStreet2>
            <rptOwnerCity>HOLLISTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>01746</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Interim CFO</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>25000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ John Fry, by power of attorney</signatureName>
        <signatureDate>2025-05-14</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
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<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>tm2514961d1_ex24.htm
<DESCRIPTION>EXHIBIT 24
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="text-align: right; margin: 0"><B>&nbsp;</B></P>

<P STYLE="text-align: right; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Exhibit 24</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>POWER OF ATTORNEY</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">KNOW ALL PERSONS BY THESE
PRESENTS, that I, MARK FROST, hereby constitute and appoint John J. Fry, Mark Mihanovic, Daniel L. Woodard, Matt Moreno, and each of them,
my true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution for me and in my name, place and stead,
to enroll me in EDGAR Next; act as an account administrator for my EDGAR account; appoint, remove and replace account administrators,
account users, and delegated entities; maintain the security of my EDGAR account, including modification of access codes; maintain, modify
and certify the accuracy of information on my EDGAR account dashboard; sign any Form&nbsp;ID (Uniform Application for Access Codes to
File on EDGAR), reports on Form&nbsp;3 (Initial Statement of Beneficial Ownership of Securities), Form&nbsp;4 (Statement of Changes in
Beneficial Ownership of Securities), Form&nbsp;5 (Annual Statement of Beneficial Ownership of Securities) and Schedules 13D and 13G relating
to transactions by me in shares of common stock or other securities of Harvard Bioscience,&nbsp;Inc. and all amendments thereto, and to
file the same, with the Securities and Exchange Commission and the appropriate securities exchange. I hereby grant unto said attorneys-in-fact
and agents, and each of them, or their substitutes, full power and authority to do and perform each and every act and thing requisite
or necessary to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as I might
or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, and each of them, or their substitutes,
may lawfully do or cause to be done by virtue hereof. The undersigned acknowledges that the foregoing attorneys-in-fact, in serving in
such capacity at the request of the undersigned, are not assuming any of the undersigned's responsibilities to comply with Sections 13
and 16 of the Securities Exchange Act of 1934. This Power of Attorney shall be effective until such time as I deliver a written revocation
thereof to the above-named attorneys-in-fact and agents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
  <TD STYLE="width: 4%"><FONT STYLE="font-size: 10pt">Dated:</FONT></TD>
  <TD STYLE="border-bottom: Black 1pt solid; padding-bottom: 1pt; width: 45%">5/14/2025</TD>
  <TD STYLE="padding-bottom: 1pt; width: 2%">&nbsp;</TD>
  <TD STYLE="border-bottom: Black 1pt solid; width: 49%">/s/ Mark Frost</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
  <TD>Mark Frost</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0">&nbsp;</P>

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</SEC-DOCUMENT>
