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<ACCESSION-NUMBER>0001144204-09-064466
<TYPE>424B3
<PUBLIC-DOCUMENT-COUNT>1
<FILING-DATE>20091214
<DATE-OF-FILING-DATE-CHANGE>20091214
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<CONFORMED-NAME>NOVELOS THERAPEUTICS, INC.
<CIK>0001279704
<ASSIGNED-SIC>2834
<IRS-NUMBER>043321804
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
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<FORM-TYPE>424B3
<ACT>33
<FILE-NUMBER>333-143263
<FILM-NUMBER>091239785
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<BUSINESS-ADDRESS>
<STREET1>ONE GATEWAY CENTER, SUITE 504
<CITY>NEWTON
<STATE>MA
<ZIP>02458
<PHONE>617-244-1616
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<STREET1>ONE GATEWAY CENTER, SUITE 504
<CITY>NEWTON
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<FORMER-CONFORMED-NAME>COMMON HORIZONS INC
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Filed
pursuant to Rule 424(b)(3)</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">File
No. 333-143263</font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Prospectus
Supplement No. 6</font></div>
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Prospectus dated April 27, 2009)</font></div>
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THERAPEUTICS,&#160;INC.</font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">12,000,000
shares of common stock</font></div>
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prospectus supplement supplements the Prospectus dated April 27, 2009, relating
to the resale of 12,000,000 shares of our common stock.&#160;&#160;This
prospectus supplement should be read in conjunction with the
Prospectus.</font></div>
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Arrangements of Certain Officers</font></div>
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December 8, 2009, the board of directors of Novelos Therapeutics, Inc. (the
&#8220;Company&#8221;) approved a special bonus plan for all employees of the Company (the
&#8220;Plan&#8221;).&#160;&#160;The Plan provides for the payment of contingent cash bonuses
in three equal installments in aggregate amounts ranging from 80% to 150% of
annual 2009 salaries for each employee.&#160;&#160;All payments under the Plan
are conditioned upon the achievement of favorable results for the Phase 3
clinical trial of NOV-002 in non-small cell lung cancer (the &#8220;Phase 3 Trial&#8221;),
as described below.</font></div>
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installment will become payable immediately upon the satisfaction of both of the
following conditions:</font></div>
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              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">the
      announcement results for the Phase 3 Trial showing statistically
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              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">the
      receipt by the Company of at least $20 million in proceeds from either the
      sale of its capital stock or a partnering transaction, or upon a change in
      control of the Company.</font></div>
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second and third installments will be payable on the first and second
anniversaries of the announcement of the results of the Phase 3 Trial following
the satisfaction of either of the following conditions:</font></div>
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              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">the
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              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">the
      results of the Phase 3 Trial show statistically significant improvement in
      median overall survival and United States Food and Drug Administration
      approves NOV-002 for use in the treatment of advanced non-small cell lung
      cancer in combination with first-line chemotherapy (paclitaxel and
      carboplatin) without requiring an additional efficacy
    trial.</font></div>
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payment of the second and third installments is subject to acceleration in the
event of a change in control of the Company, provided that the above conditions
have been satisfied.</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
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the Company&#8217;s employees are eligible for participation in the Plan, including
the following executive officers, who were identified as Named Executive
Officers, or NEOs, in our annual report on Form 10-K for the year ended December
31, 2008.&#160;&#160;If the conditions to the payments of the bonuses provided
under the Plan are satisfied, our NEOs will receive the following
amounts:</font></div>
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            <td align="left" nowrap valign="bottom" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
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              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">Christopher
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            <td align="left" valign="bottom" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">
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    <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
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      <div id="PN" style="PAGE-BREAK-AFTER: always">
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
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in our common stock involves a high degree of risk.</font></div>
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Risk Factors beginning on page&#160;7 of the Prospectus.</font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Neither
the Securities and Exchange Commission nor any state securities commission has
approved or </font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">disapproved
of these securities or passed on the adequacy or accuracy of this prospectus
supplement.&#160;&#160;</font></div>
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representation to the contrary is a criminal offense.</font></div>
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of this prospectus supplement is December 14, 2009</font></div>
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