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<!-- EDGAR Online I-Metrix Xcelerate Taxonomy Schema, based on XBRL 2.1  http://www.edgar-online.com/ -->
<!-- Version: 6.12.8 -->
<!-- Round: 46fe4b0a-935c-45f1-95b0-e159dfba7207 -->
<!-- Creation date: 2011-11-08T18:13:49Z -->
<!-- Copyright (c) 2005-2011 EDGAR Online, Inc. All Rights Reserved. -->
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      <link:roleType roleURI="http://www.novelos.com/taxonomy/role/DocumentDocumentandEntityInformation" id="DocumentDocumentandEntityInformation">
        <link:definition>101 - Document - Document and Entity Information</link:definition>
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        <link:definition>103 - Statement - BALANCE SHEETS</link:definition>
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        <link:definition>104 - Statement - BALANCE SHEETS (Parenthetical)</link:definition>
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        <link:definition>105 - Statement - STATEMENTS OF OPERATIONS</link:definition>
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        <link:definition>106 - Statement - STATEMENTS OF STOCKHOLDERS' EQUITY</link:definition>
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        <link:definition>108 - Statement - STATEMENTS OF CASH FLOWS</link:definition>
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        <link:definition>107 - Statement - STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical)</link:definition>
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        <link:definition>109 - Disclosure - NATURE OF BUSINESS, BASIS OF PRESENTATION</link:definition>
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        <link:definition>110 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES</link:definition>
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        <link:definition>111 - Disclosure - FAIR VALUES OF ASSETS AND LIABILITIES</link:definition>
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        <link:definition>112 - Disclosure - ACQUISITION</link:definition>
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        <link:definition>113 - Disclosure - FIXED ASSETS</link:definition>
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        <link:definition>114 - Disclosure - LICENSE AGREEMENTS</link:definition>
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        <link:definition>115 - Disclosure - CONVERTIBLE DEBT</link:definition>
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        <link:definition>116 - Disclosure - LONG-TERM NOTES PAYABLE</link:definition>
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        <link:definition>117 - Disclosure - LINE OF CREDIT</link:definition>
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        <link:definition>118 - Disclosure - STOCKHOLDERS' DEFICIENCY</link:definition>
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        <link:definition>119 - Disclosure - STOCK-BASED COMPENSATION</link:definition>
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        <link:definition>120 - Disclosure - INCOME TAXES</link:definition>
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        <link:definition>121 - Disclosure - NET INCOME (LOSS) PER SHARE</link:definition>
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        <link:definition>122 - Disclosure - COMMITMENTS</link:definition>
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        <link:definition>123 - Disclosure - LITIGATION</link:definition>
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        <link:definition>124 - Disclosure - EMPLOYEE RETIREMENT PLAN</link:definition>
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        <link:definition>125 - Disclosure - RELATED PARTY TRANSACTIONS</link:definition>
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        <link:definition>126 - Disclosure - (UNAUDITED) SUPPLEMENTAL PRO FORMA INFORMATION</link:definition>
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        <link:definition>127 - Disclosure - PROPOSED REVERSE STOCK SPLIT</link:definition>
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        <link:definition>128 - Disclosure - COLLABORATION AGREEMENTS</link:definition>
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        <link:definition>129 - Disclosure - SUBSEQUENT EVENTS</link:definition>
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  <element name="SeriesEConvertiblePreferredStockAndAccumulatedDividendsMember" id="nvlt_SeriesEConvertiblePreferredStockAndAccumulatedDividendsMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="StockIssuedDuringPeriodSharesPreferredStockAndCommonStockWarrants" id="nvlt_StockIssuedDuringPeriodSharesPreferredStockAndCommonStockWarrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="StockIssuedDuringPeriodSharesStockWarrantsExercised" id="nvlt_StockIssuedDuringPeriodSharesStockWarrantsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="StockIssuedDuringPeriodValuePreferredStockAndCommonStockWarrants" id="nvlt_StockIssuedDuringPeriodValuePreferredStockAndCommonStockWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="StockIssuedDuringPeriodValueStockWarrantsExercised" id="nvlt_StockIssuedDuringPeriodValueStockWarrantsExercised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="SupplementalFinancialInformationDisclosureTextBlock" id="nvlt_SupplementalFinancialInformationDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="SupplementalIssuanceOfStockAndWarrants" id="nvlt_SupplementalIssuanceOfStockAndWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="TemporaryEquitySharesDesignated" id="nvlt_TemporaryEquitySharesDesignated" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="WeightedAverageNumberBasicDilutedSharesOutstanding" id="nvlt_WeightedAverageNumberBasicDilutedSharesOutstanding" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
</schema>
