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STOCK-BASED COMPENSATION (Tables) | 12 Months Ended
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Dec. 31, 2014
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] |
Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Table Text Block] | The following table summarizes amounts charged to expense for stock-based compensation related to employee and director stock option grants and recorded in connection with stock options granted to non-employee consultants:
|  | Year Ended December 31, |
|  | 2014 |  | 2013 |
Employee and director stock option grants: |  |  |  |  |  |  |
Research and development |  | $ | 174,666 |  | $ | 355,012 |
General and administrative |  |  | 621,563 |  |  | 1,229,617 |
Restructuring costs |  |  | 47,853 |  |  | 705,518 |
|  |  | 844,082 |  |  | 2,290,147 |
Non-employee consultant stock option grants: |  |  |  |  |  |  |
Research and development |  |  | 6,268 |  |  | 21,516 |
General and administrative |  |  | — |  |  | 11,570 |
|  |  | 6,268 |  |  | 33,086 |
Total stock-based compensation |  | $ | 850,350 |  | $ | 2,323,233 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] | The following table summarizes weighted-average values and assumptions used for options granted to employees, directors and consultants in the periods indicated:
|  | Year Ended December 31, |
|  | 2014 |  |  | 2013 |
Volatility |  |  | 107%-109 | % |  |  | 109 | %
Risk-free interest rate |  |  | 1.76%-1.83 | % |  |  | 0.92% - 2.05 | %
Expected life (years) |  |  | 6 |  |  |  | 5.75 - 6.55 |
Dividend |  |  | 0 | % |  |  | 0 | %
Weighted-average exercise price |  | $ | 3.69 |  |  | $ | 9.20 |
Weighted-average grant-date fair value |  | $ | 3.01 |  |  | $ | 5.60 |
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] | A summary of stock option activity is as follows:
|  | Number of Shares Issuable Upon |  |  |  |  | Weighted Average Remaining |  |  |  |
|  | Exercise of Outstanding Options |  | Weighted Average Exercise Price |  | Contracted Term in Years |  | Aggregate Intrinsic Value |
Outstanding at December 31, 2012 |  |  | 321,959 |  | $ | 30.40 |  |  |  |  |  |  |
Granted |  |  | 344,278 |  | $ | 9.20 |  |  |  |  |  |  |
Canceled |  |  | (9,452) |  | $ | 117.80 |  |  |  |  |  |  |
Forfeited |  |  | (22,127) |  | $ | 15.60 |  |  |  |  |  |  |
Outstanding at December 31, 2013 |  |  | 634,658 |  | $ | 18.07 |  |  |  |  |  |  |
Granted |  |  | 120,300 |  | $ | 3.69 |  |  |  |  |  |  |
Canceled |  |  | (18,437) |  | $ | 24.19 |  |  |  |  |  |  |
Forfeited |  |  | (17,055) |  | $ | 14.58 |  |  |  |  |  |  |
Outstanding at December 31, 2014 |  |  | 719,466 |  | $ | 15.59 |  |  |  |  |  |  |
Vested, December 31, 2014 |  |  | 333,907 |  | $ | 24.53 |  |  | 4.61 |  | $ | — |
Unvested, December 31, 2014 |  |  | 385,559 |  | $ | 7.85 |  |  | 9.09 |  | $ | 17,500 |
Exercisable at December 31, 2014 |  |  | 333,907 |  | $ | 24.53 |  |  | 4.61 |  | $ | — |

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- Definition Tabular disclosure of the amount of total share-based compensation cost, including the amounts attributable to each share-based compensation plan and any related tax benefits. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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