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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) | Total | Preferred Stock [Member] | Common Stock [Member] | Additional Paid-In Capital [Member] | Accumulated Deficit [Member]
--- | --- | --- | --- | --- | ---
BALANCE AT DECEMBER at Dec. 31, 2016 | $ 13,539,872 | $ 865,136 | $ 10 | $ 83,461,752 | $ (70,787,026)
BALANCE AT DECEMBER (in shares) at Dec. 31, 2016 |  | 17 | 1,036,832 |  |
Issuance of common stock, warrants and preferred stock, net of issuance costs | 7,054,865 | $ 2,265,257 | $ 2 | 4,789,606 | 0
Issuance of common stock, warrants and preferred stock, net of issuance costs (in shares) |  | 41 | 195,438 |  |
Warrant exercises | 2,963,259 | $ 0 | $ 2 | 2,963,257 | 0
Warrant exercises (in shares) |  | 0 | 197,550 |  |
Stock-based compensation | 758,757 | $ 0 | $ 0 | 758,757 | 0
Cashless option exercise | 0 | $ 0 | $ 0 | 0 | 0
Cashless option exercise (in shares) |  | 0 | 240 |  |
Conversion of preferred shares into common shares | 0 | $ (2,134,611) | $ 2 | 2,134,609 | 0
Conversion of preferred shares into common shares (in shares) |  | (40) | 236,084 |  |
Net loss | (13,562,290) | $ 0 | $ 0 | 0 | (13,562,290)
BALANCE AT DECEMBER at Dec. 31, 2017 | 10,754,463 | $ 995,782 | $ 16 | 94,107,981 | (84,349,316)
BALANCE AT DECEMBER (in shares) at Dec. 31, 2017 |  | 18 | 1,666,144 |  |
Issuance of common stock, warrants and preferred stock, net of issuance costs | 15,025,078 | $ 5,949,301 | $ 14 | 9,075,763 | 0
Issuance of common stock, warrants and preferred stock, net of issuance costs (in shares) |  | 1,114 | 1,355,000 |  |
Stock-based compensation | 721,209 | $ 0 | $ 0 | 721,209 | 0
Vested restricted stock | 0 | $ 0 | $ 0 | 0 | 0
Vested restricted stock (in shares) |  | 0 | 12,667 |  |
Reverse stock split fractional shares | (762) | $ 0 | $ 0 | (762) | 0
Reverse stock split fractional shares (in shares) |  | 0 | (105) |  |
Retired shares | 0 | $ 0 | $ 0 | 0 | 0
Retired shares (in shares) |  | 0 | (104) |  |
Conversion of preferred shares into common shares | 0 | $ (4,419,034) | $ 17 | 4,419,017 | 0
Conversion of preferred shares into common shares (in shares) |  | (659) | 1,698,785 |  |
Net loss | (13,239,027) | $ 0 | $ 0 | 0 | (13,239,027)
BALANCE AT DECEMBER at Dec. 31, 2018 | $ 13,260,961 | $ 2,526,049 | $ 47 | $ 108,323,208 | $ (97,588,343)
BALANCE AT DECEMBER (in shares) at Dec. 31, 2018 |  | 473 | 4,732,387 |  |

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