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STOCK-BASED COMPENSATION (Tables) | 12 Months Ended
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Dec. 31, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] |
Schedule of Share-based Compensation, Restricted Stock Units Award Activity [Table Text Block] | The following table summarizes the restricted stock grants:
|  | Number of Shares |  |  | Weighted Average Grant Date Fair Value Per Share |  |  | Total Grant Date Fair Value |
Outstanding at December 31, 2016 |  |  | — |  |  |  | — |  |  |  | — |
Granted |  |  | 46,000 |  |  | $ | 20.96 |  |  | $ | 964,000 |
Vested |  |  | — |  |  |  | — |  |  |  | — |
Forfeited |  |  | (8,000 | ) |  |  | 21.00 |  |  |  | (168,000 | )
Outstanding at December 31, 2017 |  |  | 38,000 |  |  |  | 20.95 |  |  |  | 796,000 |
Granted |  |  | — |  |  |  | — |  |  |  | — |
Vested |  |  | (12,665 | ) |  |  | 20.95 |  |  |  | (265,000 | )
Forfeited |  |  | (6,667 | ) |  |  | 20.80 |  |  |  | (139,000 | )
Outstanding at December 31, 2018 |  |  | 18,668 |  |  | $ | 21.00 |  |  | $ | 392,000 |
Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Table Text Block] | The following table summarizes amounts charged to expense for stock-based compensation related to employee and director stock option grants:
|  | Year Ended December 31, |
|  | 2018 |  |  | 2017 |
Employee and director stock options and stock grants: |  |  |  |  |  |  |  |
Research and development |  | $ | 94,865 |  |  | $ | 147,821 |
General and administrative |  |  | 626,344 |  |  |  | 610,936 |
Total stock-based compensation |  | $ | 721,209 |  |  | $ | 758,757 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] | The following table summarizes weighted-average values and assumptions used for options granted to employees, directors and consultants in the periods indicated:
|  | Year Ended December 31, |
|  | 2018 |  |  | 2017 |
Volatility |  |  | 91-106 | % |  |  | 107-110 | %
Risk-free interest rate |  |  | 2.64-3.05 | % |  |  | 1.89-2.18 | %
Expected life (years) |  |  | 6 |  |  |  | 6 |
Dividend |  |  | 0 | % |  |  | 0 | %
Weighted-average exercise price |  | $ | 2.99 |  |  | $ | 1.91 |
Weighted-average grant-date fair value |  | $ | 2.30 |  |  | $ | 1.58 |
Share-based Compensation, Stock Options, Activity [Table Text Block] | A summary of stock option activity is as follows:
|  | Number of Shares Issuable Upon Exercise of Outstanding Options |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contracted Term in Years |  |  | Aggregate Intrinsic Value |
Outstanding at December 31, 2016 |  |  | 47,133 |  |  | $ | 75.90 |  |  |  |  |  |  |  |  |
Granted |  |  | 11,230 |  |  | $ | 19.10 |  |  |  |  |  |  |  |  |
Exercised |  |  | (2,083 | ) |  | $ | 14.80 |  |  |  |  |  |  |  |  |
Expired |  |  | (201 | ) |  | $ | 1,166.10 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (2,914 | ) |  | $ | 14.80 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2017 |  |  | 53,165 |  |  | $ | 73.82 |  |  |  |  |  |  |  |  |
Granted |  |  | 184,129 |  |  | $ | 2.99 |  |  |  |  |  |  |  |  |
Expired |  |  | (2,344 | ) |  | $ | 463.16 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (2,607 | ) |  | $ | 19.46 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2018 |  |  | 232,343 |  |  | $ | 14.37 |  |  |  |  |  |  |  |  |
Exercisable, December 31, 2018 |  |  | 45,448 |  |  | $ | 51.97 |  |  |  | 7.85 |  |  | $ | — |
Unvested, December 31, 2018 |  |  | 186,895 |  |  | $ | 5.23 |  |  |  | 9.65 |  |  | $ | — |

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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 + Details
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