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STOCK-BASED COMPENSATION (Details 1) - USD ($) | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items] |  |
Total stock-based compensation | $ 721,209 | $ 758,757
Employee and director stock option grants [Member] | Research and development [Member] |  |
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items] |  |
Total stock-based compensation | 94,865 | 147,821
Employee and director stock option grants [Member] | General and administrative [Member] |  |
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items] |  |
Total stock-based compensation | $ 626,344 | $ 610,936

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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
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