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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) | Preferred Stock [Member] | Common Stock [Member] | Additional Paid-In Capital [Member] | Accumulated Deficit [Member] | Total
--- | --- | --- | --- | --- | ---
BALANCE at Dec. 31, 2018 | $ 2,526,049 | $ 47 | $ 108,323,208 | $ (97,588,343) | $ 13,260,961
BALANCE (in shares) at Dec. 31, 2018 | 473 | 4,732,387 |  |  |
Stock-based compensation |  |  | 866,791 |  | 866,791
Vested restricted stock (in shares) |  | 9,334 |  |  |
Issuance of common stock, warrants and preferred stock, net of issuance costs |  | $ 40 | 9,024,529 |  | 9,024,569
Issuance of common stock, warrants and preferred stock, net of issuance costs (in shares) |  | 4,000,000 |  |  |
Retired shares (in shares) |  | (32) |  |  |
Conversion of preferred stock to common stock | $ (1,377,845) | $ 7 | 1,377,838 |  | 1,377,845
Conversion of preferred shares into common shares (in shares) | (258) | 645,000 |  |  |
Net loss |  |  |  | (14,092,912) | (14,092,912)
BALANCE at Dec. 31, 2019 | $ 1,148,204 | $ 94 | 119,592,366 | (111,681,255) | 9,059,409
BALANCE (in shares) at Dec. 31, 2019 | 215 | 9,386,689 |  |  |
Stock-based compensation |  |  | 467,541 |  | 467,541
Vested restricted stock (in shares) |  | 9,334 |  |  |
Issuance of common stock, warrants and preferred stock, net of issuance costs | $ 18,887,645 | $ 327 | 40,831,284 |  | 59,719,256
Issuance of common stock, warrants and preferred stock, net of issuance costs (in shares) | 1,519 | 32,749,764 |  |  |
Retired shares (in shares) |  | (133) |  |  |
Conversion of warrants into common shares |  | $ 33 | 642,462 |  | 642,495
Conversion of warrants into common shares (in shares) |  | 3,297,075 |  |  |
Net loss |  |  |  | (15,094,172) | (15,094,172)
BALANCE at Dec. 31, 2020 | $ 20,035,849 | $ 454 | $ 161,533,653 | $ (126,775,427) | $ 54,794,529
BALANCE (in shares) at Dec. 31, 2020 | 1,734 | 45,442,729 |  |  |

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