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STOCK-BASED COMPENSATION (Tables) | 12 Months Ended
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Dec. 31, 2025
STOCK-BASED COMPENSATION |
Summary of the expense for stock-based compensation related to stock option grants | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Twelve Months Ended
​ | ​ | December 31,
​ | ​ ​ ​ | 2025 | ​ ​ ​ | 2024
Employee and director stock option and stock grants: | ​ | ​ | ​ | ​ | ​ | ​
Research and development | ​ | $ | 413,022 | ​ | $ | 3,486,168
General and administrative | ​ |  | 1,850,682 | ​ | ​ | 786,612
Total stock-based compensation | ​ | $ | 2,263,704 | ​ | $ | 4,272,780
Schedule of assumptions used for stock | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year Ended December 31, |
​ | ​ ​ ​ | 2025 | ​ ​ ​ | 2024 |
Volatility |  | ​ | 100.17 | % | ​ | 82.13 | %
Risk-free interest rate |  | ​ | 4.37 | % | ​ | 4.21-4.64 | %
Expected life (years) |  | ​ | 6.0 |  | ​ | 6.0 | ​
Dividend |  | ​ | 0 | % | ​ | 0 | %
Summary of stock options activity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Number of | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Shares | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Issuable | ​ | ​ | ​ | ​ | Weighted | ​ | ​ | ​
​ | ​ | Upon | ​ | ​ | ​ | ​ | Average | ​ | ​ | ​
​ | ​ | Exercise | ​ | Weighted | ​ | Remaining | ​ | ​ | ​
​ | ​ | of | ​ | Average | ​ | Contracted | ​ | Aggregate
​ |  | Outstanding | ​ | Exercise |  | Term in | ​ | Intrinsic
​ | ​ ​ ​ | Options | ​ ​ ​ | Price | ​ ​ ​ | Years | ​ ​ ​ | Value
Outstanding as of December 31, 2023 |  | 78,397 | ​ | $ | 163.80 |  | 8.64 |  | $ | 1,682,667
Granted |  | 102,116 | ​ | $ | 81.60 |  | ​ |  | ​ | ​
Expired |  | (53) | ​ | $ | 600.00 |  | ​ |  | ​ | ​
Forfeited |  | (27,503) | ​ | $ | 75.30 |  | ​ |  | ​ | ​
Exercised |  | (55) | ​ | $ | 50.40 |  | ​ |  | ​ | ​
Outstanding as of December 31, 2024 | ​ | 152,902 | ​ | $ | 123.00 | ​ | 7.37 | ​ | $ | —
Granted | ​ | 77,331 | ​ | $ | 8.70 | ​ | ​ | ​ | ​ | ​
Expired | ​ | (18,066) | ​ | $ | 125.25 | ​ | ​ | ​ | ​ | ​
Outstanding as of December 31, 2025 | ​ | 212,167 | ​ | $ | 80.47 | ​ | 5.35 | ​ | $ | —
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Exercisable as of December 31, 2025 |  | 113,080 | ​ | $ | 129.93 |  | ​ | ​ | $ | —
Unvested as of December 31, 2025 |  | 99,087 | ​ | $ | 24.03 |  | ​ | ​ | $ | —

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