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Condensed Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Operating activities    
Net loss $ (17,574) $ (16,194)
Adjustment to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 105 37
Stock-based compensation 1,202 561
Net amortization of premium/ discounts on marketable securities 178 0
Changes in operating assets and liabilities:    
Grant reimbursement and other receivables (123) 61
Prepaid expenses and other assets 134 (217)
Accounts payable (2,883) 1,290
Accrued expenses (271) (57)
Net cash used in operating activities (19,232) (14,519)
Investing activities    
Purchases of marketable securities (79,786) 0
Maturities of marketable securities 39,900 0
Restricted cash (2,431) 0
Purchases of property and equipment (1,215) (187)
Net cash used in investing activities (43,532) (187)
Financing activities    
Proceeds from issuance of convertible preferred stock, net of issuance costs 0 41,023
Proceeds from the exercise of stock options 9 67
Cash provided by financing activities 9 41,090
Net increase (decrease) in cash and cash equivalents (62,755) 26,384
Cash and cash equivalents at beginning of period 89,713 9,319
Cash and cash equivalents at end of period 26,958 35,703
Supplemental disclosures for non- cash investing activities:    
Property & equipment purchased in accounts payable $ 412 $ 0