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v3.19.1

Significant Agreements - Additional Information (Detail) |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended
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Dec. 18, 2018 | Sep. 27, 2018 USD ($) Milestone | Sep. 30, 2018 USD ($) | May 31, 2017 USD ($) | Apr. 30, 2017 USD ($) shares | Dec. 31, 2015 USD ($) | Dec. 31, 2018 USD ($) | Sep. 30, 2018 USD ($) | Jun. 30, 2018 USD ($) | Mar. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Sep. 30, 2017 USD ($) | Jun. 30, 2017 USD ($) | Mar. 31, 2017 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increase (decrease) in deferred revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (520,000) | $ (444,000)
Recognition of revenue |  |  |  |  |  |  | $ 111,000 | $ 1,801,000 | $ 254,000 | $ 354,000 | $ 111,000 | $ 111,000 | $ 2,111,000 | $ 111,000 | 2,520,000 | 2,444,000
Deferred revenue included in current liabilities |  |  |  |  |  |  | 268,000 |  |  |  | $ 444,000 |  |  |  | 268,000 | 444,000
AbbVie Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of mile stone payments under second phase | Milestone |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Initial milestone payment upon execution of amendment |  | $ 2,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increase in transaction price of performance obligation of second phase |  | $ 2,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative catch-up adjustment to revenue, contract modification |  |  | $ 1,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Increase (decrease) in deferred revenue |  |  | $ 300,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Recognition of revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,500,000 | $ 2,400,000
Deferred revenue included in current liabilities |  |  |  |  |  |  | $ 300,000 |  |  |  |  |  |  |  | 300,000 |
AbbVie Agreement | IBDCo |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront non refundable payment |  |  |  |  |  | $ 2,000,000 |  |  |  |  |  |  |  |  |  |
Potential milestone payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 16,500,000 |
Collaboration in research and development |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 54 months |
Milestone payment |  |  |  | $ 2,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Massachusetts Institute of Technology and Boston University License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Type of Cost, Good or Service [Extensible List] |  |  |  |  | us-gaap:LicenseAndServiceMember |  |  |  |  |  |  |  |  |  |  |
Recognition of license fees |  |  |  |  | $ 1,800,000 |  |  |  |  |  |  |  |  |  |  |
Payment for prior patent costs |  |  |  |  | 300,000 |  |  |  |  |  |  |  |  |  |  |
Massachusetts Institute of Technology and Boston University License Agreement | Intellectual Property |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License acquired |  |  |  |  | $ 50,000 |  |  |  |  |  |  |  |  |  |  |
Massachusetts Institute of Technology and Boston University License Agreement | Common Stock | 2017 Reorganization |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, converted | shares |  |  |  |  | 325,377 |  |  |  |  |  |  |  |  |  |  |
Massachusetts Institute of Technology and Boston University License Agreement | Common units |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common units issued for license | shares |  |  |  |  | 325,377 |  |  |  |  |  |  |  |  |  |  |
Massachusetts Institute of Technology and Boston University License Agreement | Mirna therapeutics | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, converted | shares |  |  |  |  | 179,999 |  |  |  |  |  |  |  |  |  |  |
Boston University License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreement termination effective date | Feb. 16, 2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Massachusetts Institute of Technology License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreement termination effective date | Jun. 19, 2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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