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Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Income Statement [Abstract]
Revenue	$ 2,520	$ 2,444
Operating expenses:
Research and development	38,034	30,341
General and administrative	15,716	12,927
Total operating expenses	53,750	43,268
Loss from operations	(51,230)	(40,824)
Other income (expense):
Interest and investment income	2,843	504
Interest expense	(43)	(57)
Other expense	(5)
Other income (expense), net	2,795	447
Net loss	$ (48,435)	$ (40,377)
Net loss per share attributable to common shareholders - basic and diluted	$ (2.03)	$ (6.00)
Weighted-average common shares used in computing net loss per share attributable to common shareholders - basic and diluted	23,882,685	6,724,641
Comprehensive loss:
Net loss	$ (48,435)	$ (40,377)
Net unrealized losses on marketable securities	(56)	(9)
Comprehensive loss	$ (48,491)	$ (40,386)

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