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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Cash flows from operating activities:    
Net loss $ (48,435) $ (40,377)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 2,421 2,310
Loss on disposal of property and equipment 8 5
Equity-based compensation expense 4,317 2,652
Common shares issued for license acquisition   1,750
Accretion/amortization of investment securities (1,401) (6)
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (45) (87)
Accounts payable and accrued expenses (257) 4,071
Deferred revenue (520) (444)
Deferred rent 1,274 (1,121)
Other assets 168 192
Net cash, cash equivalents and restricted cash used in operating activities (42,470) (31,055)
Cash flows from investing activities:    
Net assets acquired in reverse merger, net of transaction costs   40,433
Purchases of marketable securities (172,887) (51,438)
Proceeds from maturity of marketable securities 91,340 22,850
Proceeds from sale of property and equipment   11
Purchases of property and equipment (5,654) (2,578)
Net cash, cash equivalents and restricted cash (used in) provided by investing activities (87,201) 9,278
Cash flows from financing activities:    
Payments on capital lease obligations (427) (408)
Proceeds from exercise of stock options 244 5
Proceeds from sale of common stock, net of issuance costs 82,666  
Proceeds from sale of convertible preferred stock, net of issuance costs   40,433
Proceeds from sale of preferred units, net of issuance costs   26,648
Net cash, cash equivalents and restricted cash provided by financing activities 82,483 66,678
Net (decrease) increase in cash, cash equivalents and restricted cash (47,188) 44,901
Cash, cash equivalents and restricted cash at beginning of period 59,537 14,636
Cash, cash equivalents and restricted cash at end of period 12,349 59,537
Supplemental disclosure of non-cash investing activities:    
Landlord funded allowance for tenant improvements 1,654 4,961
Property and equipment purchases included in accounts payable and accrued expenses 169 147
Supplemental disclosure of non-cash financing activities:    
Cash paid for interest 43 35
Purchase under capital lease $ 12 918
Prior period adjustment related to the adoption of ASU 2016-09   $ 29