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Selected Quarterly Data (unaudited) (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Quarterly Financial Information Disclosure [Abstract]                    
Revenue $ 111 $ 1,801 $ 254 $ 354 $ 111 $ 111 $ 2,111 $ 111 $ 2,520 $ 2,444
Operating expenses 12,819 13,335 15,606 11,990 12,029 12,186 11,568 7,485 53,750 43,268
Loss from operations (12,708) (11,534) (15,352) (11,636) (11,918) (12,075) (9,457) (7,374) (51,230) (40,824)
Net loss $ (11,931) $ (10,748) $ (14,591) $ (11,165) $ (11,697) $ (11,924) $ (9,388) $ (7,368) $ (48,435) $ (40,377)
Net loss per share attributable to common stockholders - basic and diluted $ (0.47) $ (0.43) $ (0.59) $ (0.55) $ (0.74) $ (1.66) $ (4.70)   $ (2.03) $ (6.00)
Net loss per unit attributable to common unit holders - basic and diluted               $ (4.49)