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Consolidated Statements of Operations (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Income Statement [Abstract]    
Revenue $ 338 $ 354
Operating expenses:    
Research and development 10,384 8,361
General and administrative 3,651 3,629
Total operating expenses 14,035 11,990
Loss from operations (13,697) (11,636)
Other income (expense):    
Interest and investment income 757 486
Interest expense (7) (14)
Other expense 1 (1)
Other income (expense), net 751 471
Net loss $ (12,946) $ (11,165)
Net loss per share attributable to common shareholders - basic and diluted $ (0.51) $ (0.55)
Weighted-average common shares used in computing net loss per share attributable to common shareholders - basic and diluted 25,293,791 20,145,881
Comprehensive loss:    
Net loss $ (12,946) $ (11,165)
Net unrealized gains (losses) on marketable securities 104 (102)
Comprehensive loss $ (12,842) $ (11,267)