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AbbVie Collaboration Agreement - Additional Information (Detail) $ in Thousands			1 Months Ended		3 Months Ended
	Dec. 18, 2018 USD ($)	Sep. 27, 2018 USD ($) Milestone	May 31, 2017 USD ($)	Dec. 31, 2015 USD ($)	Mar. 31, 2019 USD ($)	Mar. 31, 2018 USD ($)	Feb. 28, 2019 USD ($)	Dec. 31, 2018 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Recognition of revenue					$ 338	$ 354
Long term deferred revenue					465
Current deferred revenue					1,964			$ 268
AbbVie Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Number of mile stone payments under second phase | Milestone		2
Initial milestone payment upon execution of amendment		$ 2,000
Increase in transaction price of performance obligation of second phase	$ 2,000
Remaining milestone achieved							$ 2,500
Recognition of revenue					300	$ 400
Long term deferred revenue					2,000
Current deferred revenue					500
AbbVie Agreement | IBDCo
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront non refundable payment				$ 2,000
Potential milestone payment					$ 16,500
Collaboration in research and development					54 months
Milestone payment			$ 2,000

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