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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Cash flows from operating activities:    
Net loss $ (12,946) $ (11,165)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 904 681
Loss on disposal of property and equipment   2
Equity-based compensation expense 954 919
Accretion/amortization of investment securities (446) (171)
Changes in operating assets and liabilities:    
Accounts receivable (2,500)  
Prepaid expenses and other current assets 152 (493)
Accounts payable and accrued expenses (1,084) (2,975)
Deferred revenue 2,161 (354)
Operating lease liability (313)  
Deferred rent   295
Other assets   230
Net cash used in operating activities (13,118) (13,031)
Cash flows from investing activities:    
Purchases of marketable securities (39,346) (74,964)
Proceeds from maturity of marketable securities 57,282 5,000
Purchases of property and equipment (261) (1,904)
Net cash provided by (used in) investing activities 17,675 (71,868)
Cash flows from financing activities:    
Payments on finance lease obligations (65) (108)
Proceeds from sale of common stock, net of issuance costs   53,752
Net cash (used in) provided by financing activities (65) 53,644
Net increase (decrease) in cash, cash equivalents and restricted cash 4,492 (31,255)
Cash, cash equivalents and restricted cash at beginning of period 12,349 59,537
Cash, cash equivalents and restricted cash at end of period 16,841 28,282
Supplemental disclosure of non-cash investing activities:    
Landlord funded allowance for tenant improvements   1,653
Property and equipment purchases included in accounts payable and accrued expenses (71) 1,047
Supplemental disclosure of non-cash financing activities:    
Cash paid for interest $ 7 $ 14