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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Cash flows from operating activities:    
Net loss $ (38,575) $ (36,504)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 2,989 1,789
Loss on disposal of property and equipment   2
Equity-based compensation expense 3,094 3,445
Accretion/amortization of investment securities (1,177) (958)
Changes in operating assets and liabilities:    
Accounts receivable   (2,000)
Prepaid expenses and other current assets (9,444) 190
Accounts payable and accrued expenses (670) (592)
Deferred revenue 1,507 (410)
Operating lease liability and right of use asset (1,407)  
Deferred rent   1,364
Prepaid research and development, net of current portion (20,571)  
Other assets   167
Net cash used in operating activities (64,254) (33,507)
Cash flows from investing activities:    
Purchases of marketable securities (129,517) (144,594)
Proceeds from maturity of marketable securities 131,146 58,730
Purchases of property and equipment (842) (4,254)
Net cash provided by (used in) investing activities 787 (90,118)
Cash flows from financing activities:    
Proceeds from exercise of stock options   103
Payments on finance lease obligations (198) (330)
Proceeds from sale of common stock, net of issuance costs 56,997 82,666
Proceeds from sale of pre-funded warrants, net of issuance costs 22,874  
Net cash provided by financing activities 79,673 82,439
Net increase (decrease) in cash, cash equivalents and restricted cash 16,206 (41,186)
Cash, cash equivalents and restricted cash at beginning of period 12,349 59,537
Cash, cash equivalents and restricted cash at end of period 28,555 18,351
Supplemental disclosure of non-cash investing activities:    
Landlord funded allowance for tenant improvements   1,654
Property and equipment purchases included in accounts payable and accrued expenses (365) 976
Assets acquired under operating lease obligation 2,714  
Supplemental disclosure of non-cash financing activities:    
Issuance costs included in accounts payable and accrued expenses 26  
Purchase under finance lease   12
Cash paid for interest $ 17 $ 35