<SEC-DOCUMENT>0000904454-19-000519.txt : 20190621
<SEC-HEADER>0000904454-19-000519.hdr.sgml : 20190621
<ACCEPTANCE-DATETIME>20190621170431
ACCESSION NUMBER:		0000904454-19-000519
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20190611
FILED AS OF DATE:		20190621
DATE AS OF CHANGE:		20190621

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Ginkgo Bioworks, Inc.
		CENTRAL INDEX KEY:			0001648827
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37566
		FILM NUMBER:		19912285

	BUSINESS ADDRESS:	
		STREET 1:		27 DRYDOCK AVENUE, 8TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		877-422-5362

	MAIL ADDRESS:	
		STREET 1:		27 DRYDOCK AVENUE, 8TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SYNLOGIC, INC.
		CENTRAL INDEX KEY:			0001527599
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				261824804
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		301 BINNEY STREET
		STREET 2:		SUITE 402
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142
		BUSINESS PHONE:		617-401-9975

	MAIL ADDRESS:	
		STREET 1:		301 BINNEY STREET
		STREET 2:		SUITE 402
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Mirna Therapeutics, Inc.
		DATE OF NAME CHANGE:	20110809
</SEC-HEADER>
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<SEQUENCE>1
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<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2019-06-11</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001527599</issuerCik>
        <issuerName>SYNLOGIC, INC.</issuerName>
        <issuerTradingSymbol>SYBX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001648827</rptOwnerCik>
            <rptOwnerName>Ginkgo Bioworks, Inc.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>27 DRYDOCK AVENUE, 8TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02210</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>6340771</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Class A Warrants to Purchase Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>.01</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2019-06-11</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2044-06-11</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>2548117</value>
                    <footnoteId id="F1"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The Warrants were exercisable immediately upon their issuance, however the terms of the Warrants include a beneficial ownership limitation pursuant to which they are exercisable only to the extent that such exercise does not result in the Reporting Person's beneficial ownership exceeding 19.99% of the Common Stock outstanding at any time.</footnote>
    </footnotes>

    <remarks>Exhibit List:  Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Reshma Shetty, Attorney-in-Fact</signatureName>
        <signatureDate>2019-06-19</signatureDate>
    </ownerSignature>
</ownershipDocument>
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<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>poa_ginkgobioworks-061919.htm
<DESCRIPTION>POWER OF ATTORNEY FOR GINKGO BIOWORKS, INC.
<TEXT>
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  <head>
    <title></title>
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         Copyright 1995 - 2019 Broadridge -->
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<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt;" bgcolor="#ffffff" text="#000000">
  <div style="text-align: center; margin-bottom: 12pt; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">EXHIBIT 24 TO FORM 3</div>
  <div style="text-align: center; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">POWER OF ATTORNEY</font></div>
  <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The undersigned hereby makes, constitutes and appoints each of</font> Reshma Shetty, Austin Che and Karen Tepichen<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> (each, an &#8220;Attorney&#8221;), signing singly, with full power of substitution, a true and lawful attorney-in-fact for the undersigned, in the undersigned&#8217;s name, place and stead and on
      the undersigned&#8217;s behalf, to complete, execute and file with the United States Securities and Exchange Commission, one or more initial statements of beneficial ownership of securities, statements of changes in beneficial ownership of securities,&#160;
      annual statements of beneficial ownership of securities and/or information statements pursuant to Sections 16(a), 13(d) and/or 13(g) of the Securities Exchange Act of 1934 and the rules and regulations thereunder, and any other amendments, forms,
      certificates, documents or instruments that the Attorney deems necessary or appropriate in order to comply with the requirements of said Sections 16(a), 13(d) and/or 13(g) and said rules and regulations.</font></div>
  <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The undersigned hereby acknowledges that the Attorneys, in serving in such capacity at the undersigned&#8217;s request, are not
      assuming any of the undersigned&#8217;s responsibilities to comply with Sections 16(a), 13(d) and/or 13(g) of the Securities Exchange Act of 1934 and the rules and regulations thereunder.</font></div>
  <div style="text-align: justify; margin-bottom: 24pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">This Power of Attorney shall remain in effect unless a written revocation thereof is delivered to the Attorneys.</font></div>
  <div style="text-align: left; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Dated:&#160; June 19, 2019.</font></div>
  <div style="text-align: left; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
    </font></div>
  <div style="text-align: left; margin-bottom: 12pt;">
    <div style="text-align: left; text-indent: 216pt; line-height: 12.55pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><u> </u>GINKGO BIOWORKS,
          INC.</font></font></div>
    <div style="text-align: left; text-indent: 216pt; line-height: 12.55pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><u><br>
          </u></font></font></div>
    <div style="text-align: left; text-indent: 216pt; line-height: 12.55pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><u><br>
          </u></font></font></div>
    <div style="text-align: left; text-indent: 216pt; line-height: 12.55pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><u>By:&#160; /s/ Jason Kelly
            &#160;&#160;&#160;&#160;&#160;&#160; <br>
          </u></font></font></div>
    <div style="text-align: left; text-indent: 36pt; margin-left: 180pt; line-height: 12.55pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Name:&#160; Jason Kelly<br>
      </font></div>
    <div style="text-align: left; text-indent: 36pt; margin-left: 180pt; line-height: 12.55pt;">Title: Chief Executive Officer<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
      </font></div>
    <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> </font></div>
  <div style="text-align: justify; margin-bottom: 12pt;"><br>
  </div>
  <div> </div>
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