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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2020
Mar. 31, 2019
Cash flows from operating activities:    
Net loss $ (15,828) $ (12,946)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 667 683
Equity-based compensation expense 1,095 954
Accretion/amortization of investment securities (45) (446)
Reduction in carrying amount of operating lease right-of-use asset 420 221
Changes in operating assets and liabilities:    
Accounts receivable   (2,500)
Prepaid expenses and other current assets 509 152
Prepaid research and development, net of current portion 3,327  
Accounts payable and accrued expenses (2,129) (1,084)
Deferred revenue (100) 2,161
Operating lease liabilities (395) (313)
Net cash used in operating activities (12,479) (13,118)
Cash flows from investing activities:    
Purchases of marketable securities (14,269) (39,346)
Proceeds from maturity of marketable securities 18,852 57,282
Proceeds from redemption of marketable securities 1,500  
Purchases of property and equipment (266) (261)
Net cash provided by investing activities 5,817 17,675
Cash flows from financing activities:    
Payments on finance lease obligations (69) (65)
Net cash used in financing activities (69) (65)
Net increase (decrease) in cash, cash equivalents and restricted cash (6,731) 4,492
Cash, cash equivalents and restricted cash at beginning of period 27,281 12,349
Cash, cash equivalents and restricted cash at end of period 20,550 16,841
Supplemental disclosure of non-cash investing and financing activities:    
Property and equipment purchases included in accounts payable and accrued expenses 41 (71)
Cash paid for interest $ 3 $ 7