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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities: |  |
Net loss | $ (60,561) | $ (59,173)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 2,443 | 2,636
Equity-based compensation expense | 3,361 | 3,907
Accretion/amortization of investment securities | 261 | (21)
Reduction in carrying amount of operating lease right of use asset | 2,098 | 1,736
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | 1,681 | 7,273
Prepaid research and development, net of current portion | 281 | 6,791
Other assets | 1 | 60
Accounts payable and accrued expenses | 538 | (349)
Deferred revenue | 531 | (544)
Operating lease liabilities | (2,701) | (2,000)
Other long-term liabilities | (131) | 131
Net cash used in operating activities | (52,198) | (39,553)
Cash flows from investing activities: |  |
Purchases of marketable securities | (167,866) | (86,474)
Proceeds from maturity of marketable securities | 114,022 | 90,836
Proceeds from redemption of marketable securities | 1,270 | 28,515
Purchases of property and equipment | (679) | (395)
Net cash (used in) provided by investing activities | (53,253) | 32,482
Cash flows from financing activities: |  |
Payments on finance lease obligations | (8) | (208)
Restricted stock awards withheld for payment of employees' withholding tax liability | (73) |
Proceeds from issuance of common stock, net of issuance costs | 81,042 |
Proceeds from employee stock purchases and exercise of stock options | 374 | 58
Net cash provided by financing activities | 89,382 | 13,394
Net (decrease) increase in cash, cash equivalents and restricted cash | (16,069) | 6,323
Cash, cash equivalents and restricted cash at beginning of period | 33,604 | 27,281
Cash, cash equivalents and restricted cash at end of period | 17,535 | 33,604
Supplemental disclosure of non-cash investing activities: |  |
Property and equipment purchases included in accounts payable and accrued expenses | 40 | (4)
Assets acquired under operating lease obligation | 460 |
Supplemental disclosure of non-cash financing activities: |  |
Purchase under finance lease | 36 |
Issuance costs included in accounts payable and accrued expenses |  | 10
Cash paid for interest | 2 | 6
At-the-market Offering |  |
Cash flows from financing activities: |  |
Proceeds from issuance of common stock, net of issuance costs | $ 8,047 | $ 13,544

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