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Document and Entity Information - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Mar. 10, 2022
Jun. 30, 2021
Cover [Abstract]      
Document Type 10-K    
Amendment Flag false    
Document Period End Date Dec. 31, 2021    
Document Fiscal Year Focus 2021    
Document Fiscal Period Focus FY    
Trading Symbol SYBX    
Entity Registrant Name SYNLOGIC, INC.    
Entity Central Index Key 0001527599    
Current Fiscal Year End Date --12-31    
Entity Well-known Seasoned Issuer No    
Entity Current Reporting Status Yes    
Entity Voluntary Filers No    
Entity Filer Category Non-accelerated Filer    
Entity Small Business true    
Entity Emerging Growth Company false    
ICFR Auditor Attestation Flag false    
Entity Shell Company false    
Entity Common Stock, Shares Outstanding   70,228,487  
Entity Public Float     $ 122.2
Title of 12(b) Security Common Stock, par value $0.001 per share    
Entity File Number 001-37566    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 26-1824804    
Entity Interactive Data Current Yes    
Security Exchange Name NASDAQ    
Entity Address, Address Line One 301 Binney St    
Entity Address, Address Line Two Suite 402    
Entity Address, City or Town Cambridge    
Entity Address, State or Province MA    
Entity Address, Postal Zip Code 02142    
City Area Code 617    
Local Phone Number 401-9975    
Document Annual Report true    
Document Transition Report false    
Auditor Firm ID 185    
Auditor Name KPMG LLP    
Auditor Location Boston, Massachusetts, U.S.    
Documents Incorporated by Reference DOCUMENTS INCORPORATED BY REFERENCE The following documents (or parts thereof) are incorporated by reference into the following parts of this Form 10-K: Certain information required in Part III of this Annual Report on Form 10-K is incorporated from the registrant’s definitive proxy statement for the 2022 annual meeting of stockholders to be filed pursuant to Regulation 14A with the Securities and Exchange Commission within 120 days of the registrant’s fiscal year ended December 31, 2021.