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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Income Statement [Abstract]    
Revenue $ 1,754 $ 545
Operating expenses:    
Research and development 47,127 47,474
General and administrative 15,392 13,537
Total operating expenses 62,519 61,011
Loss from operations (60,765) (60,466)
Other income (expense):    
Interest and investment income 210 1,302
Interest expense (2) (6)
Other expense (4) (3)
Other income (expense), net 204 1,293
Net loss $ (60,561) $ (59,173)
Net loss per share - basic and diluted $ (1.09) $ (1.65)
Weighted-average common stock outstanding - basic and diluted 55,329,711 35,835,744
Comprehensive loss:    
Net loss $ (60,561) $ (59,173)
Net unrealized loss on marketable securities (59) (96)
Comprehensive loss $ (60,620) $ (59,269)