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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Cash flows from operating activities:    
Net loss $ (60,561) $ (59,173)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 2,443 2,636
Equity-based compensation expense 3,361 3,907
Accretion/amortization of investment securities 261 (21)
Reduction in carrying amount of operating lease right of use asset 2,098 1,736
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 1,681 7,273
Prepaid research and development, net of current portion 281 6,791
Other assets 1 60
Accounts payable and accrued expenses 538 (349)
Deferred revenue 531 (544)
Operating lease liabilities (2,701) (2,000)
Other long-term liabilities (131) 131
Net cash used in operating activities (52,198) (39,553)
Cash flows from investing activities:    
Purchases of marketable securities (167,866) (86,474)
Proceeds from maturity of marketable securities 114,022 90,836
Proceeds from redemption of marketable securities 1,270 28,515
Purchases of property and equipment (679) (395)
Net cash (used in) provided by investing activities (53,253) 32,482
Cash flows from financing activities:    
Payments on finance lease obligations (8) (208)
Restricted stock awards withheld for payment of employees' withholding tax liability (73)  
Proceeds from issuance of common stock, net of issuance costs 81,042  
Proceeds from employee stock purchases and exercise of stock options 374 58
Net cash provided by financing activities 89,382 13,394
Net (decrease) increase in cash, cash equivalents and restricted cash (16,069) 6,323
Cash, cash equivalents and restricted cash at beginning of period 33,604 27,281
Cash, cash equivalents and restricted cash at end of period 17,535 33,604
Supplemental disclosure of non-cash investing activities:    
Property and equipment purchases included in accounts payable and accrued expenses 40 (4)
Assets acquired under operating lease obligation 460  
Supplemental disclosure of non-cash financing activities:    
Purchase under finance lease 36  
Issuance costs included in accounts payable and accrued expenses   10
Cash paid for interest 2 6
At-the-market Offering    
Cash flows from financing activities:    
Proceeds from issuance of common stock, net of issuance costs $ 8,047 $ 13,544