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Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($) $ in Thousands | Total | At-the-market Offering | Common Stock $0.001 Par Value | Common Stock $0.001 Par Value At-the-market Offering | Additional Paid-in Capital | Additional Paid-in Capital At-the-market Offering | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2020 | $ 115,135 |  | $ 38 |  | $ 345,394 |  | $ 14 | $ (230,311)
Balance (in Shares) at Dec. 31, 2020 |  |  | 38,183,273 |  |  |  |  |
Balance at Mar. 31, 2021 | 109,050 |  | $ 41 |  | 354,286 |  | 5 | (245,282)
Balance (in Shares) at Mar. 31, 2021 |  |  | 40,873,526 |  |  |  |  |
Balance at Dec. 31, 2020 | 115,135 |  | $ 38 |  | 345,394 |  | 14 | (230,311)
Balance (in Shares) at Dec. 31, 2020 |  |  | 38,183,273 |  |  |  |  |
Exercise of options | 64 |  |  |  | 64 |  |  |
Exercise of options, shares |  |  | 32,113 |  |  |  |  |
Issuance of common stock under employee stock purchase plan | 33 |  |  |  | 33 |  |  |
Issuance of common stock under employee stock purchase plan, Shares |  |  | 19,061 |  |  |  |  |
Proceeds from issuance of common stock, net of issuance costs | 32,575 | $ 8,050 | $ 11 | $ 3 | 32,564 | $ 8,047 |  |
Proceeds from issuance of common stock, net of issuance costs, Shares |  |  | 11,500,000 | 2,447,211 |  |  |  |
Issuance of restricted stock, shares |  |  | 242,454 |  |  |  |  |
Restricted stock awards withheld for payment of employees' withholding tax liability | (73) |  |  |  | (73) |  |  |
Restricted stock awards withheld for payment of employees' withholding tax liability, Shares |  |  | 18,187 |  |  |  |  |
Cancellation of restricted stock |  |  | 30,581 |  |  |  |  |
Equity-based compensation expense | 1,753 |  |  |  | 1,753 |  |  |
Unrealized gain (loss) on securities | (3) |  |  |  |  |  | (3) |
Net loss | (29,456) |  |  |  |  |  |  | (29,456)
Balance at Jun. 30, 2021 | 128,078 |  | $ 52 |  | 387,782 |  | 11 | (259,767)
Balance (in Shares) at Jun. 30, 2021 |  |  | 52,375,344 |  |  |  |  |
Balance at Mar. 31, 2021 | 109,050 |  | $ 41 |  | 354,286 |  | 5 | (245,282)
Balance (in Shares) at Mar. 31, 2021 |  |  | 40,873,526 |  |  |  |  |
Exercise of options | 64 |  |  |  | 64 |  |  |
Exercise of options, shares |  |  | 31,897 |  |  |  |  |
Proceeds from issuance of common stock, net of issuance costs | 32,575 |  | $ 11 |  | 32,564 |  |  |
Proceeds from issuance of common stock, net of issuance costs, Shares |  |  | 11,500,000 |  |  |  |  |
Restricted stock awards withheld for payment of employees' withholding tax liability | (8) |  |  |  | (8) |  |  |
Restricted stock awards withheld for payment of employees' withholding tax liability, Shares |  |  | 2,217 |  |  |  |  |
Cancellation of restricted stock |  |  | 27,862 |  |  |  |  |
Equity-based compensation expense | 876 |  |  |  | 876 |  |  |
Unrealized gain (loss) on securities | 6 |  |  |  |  |  | 6 |
Net loss | (14,485) |  |  |  |  |  |  | (14,485)
Balance at Jun. 30, 2021 | 128,078 |  | $ 52 |  | 387,782 |  | 11 | (259,767)
Balance (in Shares) at Jun. 30, 2021 |  |  | 52,375,344 |  |  |  |  |
Balance at Dec. 31, 2021 | 147,266 |  | $ 70 |  | 438,113 |  | (45) | (290,872)
Balance (in Shares) at Dec. 31, 2021 |  |  | 69,698,844 |  |  |  |  |
Exercise of options | 61 |  |  |  | 61 |  |  |
Exercise of options, shares |  |  | 35,562 |  |  |  |  |
Issuance of common stock under employee stock purchase plan | 83 |  |  |  | 83 |  |  |
Issuance of common stock under employee stock purchase plan, Shares |  |  | 40,490 |  |  |  |  |
Issuance of restricted stock, shares |  |  | 507,260 |  |  |  |  |
Cancellation of restricted stock |  |  | 51,921 |  |  |  |  |
Equity-based compensation expense | 1,867 |  |  |  | 1,867 |  |  |
Unrealized gain (loss) on securities | (388) |  |  |  |  |  | (388) |
Net loss | (31,539) |  |  |  |  |  |  | (31,539)
Balance at Jun. 30, 2022 | 117,350 |  | $ 70 |  | 440,124 |  | (433) | (322,411)
Balance (in Shares) at Jun. 30, 2022 |  |  | 70,230,235 |  |  |  |  |
Balance at Mar. 31, 2022 | 132,294 |  | $ 70 |  | 439,138 |  | (345) | (306,569)
Balance (in Shares) at Mar. 31, 2022 |  |  | 70,267,586 |  |  |  |  |
Exercise of options | 9 |  |  |  | 9 |  |  |
Exercise of options, shares |  |  | 4,940 |  |  |  |  |
Issuance of common stock under employee stock purchase plan, Shares |  |  | (38) |  |  |  |  |
Cancellation of restricted stock |  |  | 42,253 |  |  |  |  |
Equity-based compensation expense | 977 |  |  |  | 977 |  |  |
Unrealized gain (loss) on securities | (88) |  |  |  |  |  | (88) |
Net loss | (15,842) |  |  |  |  |  |  | (15,842)
Balance at Jun. 30, 2022 | $ 117,350 |  | $ 70 |  | $ 440,124 |  | $ (433) | $ (322,411)
Balance (in Shares) at Jun. 30, 2022 |  |  | 70,230,235 |  |  |  |  |

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