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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Cash flows from operating activities:    
Net loss $ (31,539) $ (29,456)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 1,257 1,232
Equity-based compensation expense 1,867 1,753
Accretion/amortization of investment securities (87) 184
Change in carrying amount of operating lease right of use asset 1,554 979
Changes in operating assets and liabilities:    
Accounts receivable   (1,000)
Prepaid expenses and other current assets 415 183
Prepaid research and development, net of current portion 1,473 1,426
Accounts payable and accrued expenses (1,599) (260)
Deferred revenue (382) 904
Operating lease liabilities (1,991) (1,264)
Other assets (14) (2)
Net cash used in operating activities (29,046) (25,321)
Cash flows from investing activities:    
Purchases of marketable securities (41,116) (74,010)
Proceeds from maturity of marketable securities 85,116 54,272
Proceeds from redemption of marketable securities   1,270
Purchases of property and equipment (629) (123)
Net cash provided by (used in) investing activities 43,371 (18,591)
Cash flows from financing activities:    
Payments on finance lease obligations (6) (3)
Proceeds from issuance of common stock, net of issuance costs   32,578
Proceeds from employee stock purchases and exercise of stock options 144 97
Payment of employee withholding taxes relating to restricted stock awards   (73)
Net cash provided by financing activities 138 40,649
Net increase (decrease) in cash, cash equivalents and restricted cash 14,463 (3,263)
Cash, cash equivalents and restricted cash at beginning of period 17,535 33,604
Cash, cash equivalents and restricted cash at end of period 31,998 30,341
Supplemental disclosure of non-cash investing activities:    
Assets acquired under operating lease obligation 2,699 460
Property and equipment purchases included in accounts payable and accrued expenses 4 225
Supplemental disclosure of non-cash financing activities:    
Purchase under finance lease   36
Issuance costs included in accounts payable and accrued expenses   3
Cash paid for interest $ 1 1
At-the-market Offering    
Cash flows from financing activities:    
Proceeds from issuance of common stock, net of issuance costs   $ 8,050