    <SEC-DOCUMENT>0000950170-23-016336-index.html : 20230501
    <SEC-HEADER>0000950170-23-016336.hdr.sgml : 20230501
    <ACCEPTANCE-DATETIME>20230501171928
    ACCESSION NUMBER:		0000950170-23-016336
    CONFORMED SUBMISSION TYPE:	DEFA14A
    PUBLIC DOCUMENT COUNT:		3
    FILED AS OF DATE:		20230501
    DATE AS OF CHANGE:		20230501

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			SYNLOGIC, INC.
    		CENTRAL INDEX KEY:			0001527599
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				261824804
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEFA14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-37566
    		FILM NUMBER:		23875181

    	BUSINESS ADDRESS:
    		STREET 1:		301 BINNEY STREET
    		STREET 2:		SUITE 402
    		CITY:			CAMBRIDGE
    		STATE:			MA
    		ZIP:			02142
    		BUSINESS PHONE:		617-401-9975

    	MAIL ADDRESS:
    		STREET 1:		301 BINNEY STREET
    		STREET 2:		SUITE 402
    		CITY:			CAMBRIDGE
    		STATE:			MA
    		ZIP:			02142

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Mirna Therapeutics, Inc.
    		DATE OF NAME CHANGE:	20110809
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEFA14A
    <SEQUENCE>1
    <FILENAME>sybx_defa14a_2022.htm
    <DESCRIPTION>DEFA14A
    <TEXT>
    Document 1 - file: sybx_defa14a_2022.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>img22762782_0.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: img22762782_0.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>img22762782_1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: img22762782_1.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>