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Segment Information | 9 Months Ended
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Sep. 30, 2025
Segment Reporting [Abstract] |
Segment Information | (13) Segment Information Operating segments are defined as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision maker (CODM) or decision-making group, in making decisions on how to allocate resources and assess performance. The principal executive officer (PEO) is the CODM. The Company operates in one operating segment; discovery and development of Synthetic Biotics. The CODM manages and allocates resources to the operations of the Company on a total company basis by assessing the overall level of resources available and how to best deploy these resources across functions and research and development projects that are in line with long-term company-wide strategic goals. In making these decisions, the PEO uses consolidated financial information for purposes of evaluating performance, forecasting future period financial results, allocating resources and setting incentive targets. The CODM performs this assessment based on the Company's consolidated net income (loss) that is reported on the consolidated statements of operations and comprehensive income (loss). Through this analysis, the CODM assesses performance by comparing actual consolidated net income (loss) versus the budget, and then decides how to allocate resources to invest in the Company's research and development programs. The measure of segment assets is reported on the consolidated balance sheets as total assets. In addition, research and development, general and administrative expenses, and restructuring charges are significant segment expenses regularly provided to the PEO with the following categories (in thousands): Research and Development
| Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
| 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Clinical research and external costs | $ | 8 |  |  | $ | (852 | ) |  | $ | 23 |  |  | $ | 4,062 |
Facility and all other costs |  | — |  |  |  | 114 |  |  |  | — |  |  |  | 3,136 |
Compensation and benefits |  | — |  |  |  | 25 |  |  |  | (7 | ) |  |  | 1,966 |
Total research and development expense | $ | 8 |  |  | $ | (713 | ) |  | $ | 16 |  |  | $ | 9,164 |
General and Administrative
| Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
| 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Consulting and professional services | $ | 625 |  |  | $ | 788 |  |  | $ | 1,851 |  |  | $ | 2,838 |
Compensation and benefits |  | 139 |  |  |  | 342 |  |  |  | 433 |  |  |  | 1,603 |
Facility and all other costs |  | 54 |  |  |  | 35 |  |  |  | 170 |  |  |  | 787 |
Total general and administrative expense | $ | 818 |  |  | $ | 1,165 |  |  | $ | 2,454 |  |  | $ | 5,228 |
Restructuring Charges
| Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
| 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Facility and all other costs | $ | — |  |  | $ | 35 |  |  | $ | (80 | ) |  | $ | 15,537 |
Compensation and benefits |  | 58 |  |  |  | 221 |  |  |  | 167 |  |  |  | 8,245 |
Consulting and professional services |  | 107 |  |  |  | 20 |  |  |  | 126 |  |  |  | 686 |
Clinical research and external costs |  | — |  |  |  | 20 |  |  |  | (17 | ) |  |  | 322 |
Total restructuring charges | $ | 165 |  |  | $ | 296 |  |  | $ | 196 |  |  | $ | 24,790 |

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- Definition The entire disclosure for reporting segments including data and tables. 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