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Segment Information - Summary of Research and Development, General and Administrative Expenses, and Restructuring Charges are Significant Segment Expenses (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 | Sep. 30, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Segment Reporting Information [Line Items] |  |  |  |
Research and development | $ 8 | $ (713) | $ 16 | $ 9,164
General and administrative | 818 | 1,165 | 2,454 | 5,228
Restructuring and other charges | 165 | 296 | 196 | 24,790
Clinical research and external costs |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Research and development | 8 | (852) | 23 | 4,062
Restructuring and other charges | 0 | 20 | (17) | 322
Facility and all other costs |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Research and development | 0 | 114 | 0 | 3,136
General and administrative | 54 | 35 | 170 | 787
Restructuring and other charges | 0 | 35 | (80) | 15,537
Compensation and benefits |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Research and development | 0 | 25 | (7) | 1,966
General and administrative | 139 | 342 | 433 | 1,603
Restructuring and other charges | 58 | 221 | 167 | 8,245
Consulting and professional services |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
General and administrative | 625 | 788 | 1,851 | 2,838
Restructuring and other charges | $ 107 | $ 20 | $ 126 | $ 686

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- Definition The aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 220 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03(4)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147483621/220-10-S99-2 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 946 -SubTopic 220 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.6-07(2)(a)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479134/946-220-S99-1 + Details
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