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        <link:definition>108 - Disclosure - Business, Acquisition of Assets and Basis of Presentation</link:definition>

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        <link:definition>109 - Disclosure - Summary of Significant Accounting Policies</link:definition>

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        <link:definition>110 - Disclosure - Fixed Assets</link:definition>

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        <link:definition>111 - Disclosure - In-Process Research and Development</link:definition>

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        <link:definition>112 - Disclosure - Patents</link:definition>

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        <link:definition>113 - Disclosure - Revenue Recognition</link:definition>

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        <link:definition>114 - Disclosure - Income Taxes</link:definition>

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        <link:definition>115 - Disclosure - Commitments and Contingencies</link:definition>

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        <link:definition>116 - Disclosure - Fair Value Considerations</link:definition>

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        <link:definition>118 - Disclosure - Equity Instruments</link:definition>

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        <link:definition>124 - Disclosure - Business, Acquisition of Assets and Basis of Presentation (Policies)</link:definition>

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        <link:definition>125 - Disclosure - Business, Acquisition of Assets and Basis of Presentation (Tables)</link:definition>

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        <link:definition>126 - Disclosure - Summary of Significant Accounting Policies (Tables)</link:definition>

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        <link:definition>127 - Disclosure - Fixed Assets (Tables)</link:definition>

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        <link:definition>128 - Disclosure - Patents (Tables)</link:definition>

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        <link:definition>130 - Disclosure - Income Taxes (Tables)</link:definition>

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        <link:usedOn>link:definitionLink</link:usedOn>

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        <link:definition>131 - Disclosure - Commitments and Contingencies (Tables)</link:definition>

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        <link:definition>132 - Disclosure - Equity Instruments (Tables)</link:definition>

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        <link:definition>133 - Disclosure - Business, Acquisition of Assets and Basis of Presentation (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

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        <link:definition>134 - Disclosure - Business, Acquisition of Assets and Basis of Presentation (Details 1)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

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        <link:definition>135 - Disclosure - Business, Acquisition of Assets and Basis of Presentation (Details 2)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

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        <link:definition>136 - Disclosure - Business, Acquisition of Assets and Basis of Presentation (Details Textual)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

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        <link:definition>137 - Disclosure - Summary of Significant Accounting Policies (Details)</link:definition>

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        <link:usedOn>link:definitionLink</link:usedOn>

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      <link:roleType roleURI="http://www.aytubio.com/role/SummaryOfSignificantAccountingPoliciesDetails1" id="SummaryOfSignificantAccountingPoliciesDetails1">
        <link:definition>138 - Disclosure - Summary of Significant Accounting Policies (Details 1)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

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        <link:definition>139 - Disclosure - Summary of Significant Accounting Policies (Details 2)</link:definition>

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        <link:definition>140 - Disclosure - Summary of Significant Accounting Policies (Details 3)</link:definition>

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        <link:definition>141 - Disclosure - Summary of Significant Accounting Policies (Details 4)</link:definition>

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        <link:definition>144 - Disclosure - In-Process Research and Development (Details Textual)</link:definition>

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        <link:definition>145 - Disclosure - Patents (Details)</link:definition>

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        <link:usedOn>link:definitionLink</link:usedOn>

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        <link:definition>146 - Disclosure - Patents (Details Textual)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>147 - Disclosure - Fair Value Considerations (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>148 - Disclosure - Fair Value Considerations (Details 1)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>149 - Disclosure - Fair Value Considerations (Details 2)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>150 - Disclosure - Fair Value Considerations (Details Textual)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>151 - Disclosure - Revenue Recognition (Details Textual)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>152 - Disclosure - Income Taxes (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.aytubio.com/role/IncomeTaxesDetails1" id="IncomeTaxesDetails1">
        <link:definition>153 - Disclosure - Income Taxes (Details 1)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>154 - Disclosure - Income Taxes (Details Textual)</link:definition>

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        <link:usedOn>link:definitionLink</link:usedOn>

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        <link:definition>155 - Disclosure - Commitments and Contingencies (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>156 - Disclosure - Commitments and Contingencies (Details 1)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>157 - Disclosure - Commitments and Contingencies (Details Textual)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

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  <element name="OfficeLeaseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_OfficeLeaseMember" />

  <element name="SheduleOfCommitmentsAndContingenciesRentExpenseTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="aytu_SheduleOfCommitmentsAndContingenciesRentExpenseTable" />

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  <element name="FinancialAssetsAndLiabilitiesNotMeasuredAtFairValueOnRecurringBasisTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_FinancialAssetsAndLiabilitiesNotMeasuredAtFairValueOnRecurringBasisTableTextBlock" />

  <element name="CoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_CoMember" />

  <element name="NcMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_NcMember" />

  <element name="ManagementFeePayablePerMonth" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="aytu_ManagementFeePayablePerMonth" />

  <element name="OperatingLeasesMonthlyBaseRentInitialYear" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_OperatingLeasesMonthlyBaseRentInitialYear" />

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  <element name="IssuanceDateMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_IssuanceDateMember" />

  <element name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityWarrantIssuances" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityWarrantIssuances" />

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  <element name="StockSubscriptionPaymentValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_StockSubscriptionPaymentValue" />

  <element name="PercentageOfOwnershipInterestHeldByNewShareholder" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="aytu_PercentageOfOwnershipInterestHeldByNewShareholder" />

  <element name="IssuanceOfCommonStockInExchangeForAcquiredAssets" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="aytu_IssuanceOfCommonStockInExchangeForAcquiredAssets" />

  <element name="PrimsolBusinessMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_PrimsolBusinessMember" />

  <element name="NoLaterThanMarch312016Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_NoLaterThanMarch312016Member" />

  <element name="NoLaterThanJune302016Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_NoLaterThanJune302016Member" />

  <element name="NoLaterThanSeptember302016Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_NoLaterThanSeptember302016Member" />

  <element name="StockSubscriptionPaymentShare" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_StockSubscriptionPaymentShare" />

  <element name="PrimsolBusinessPurchaseIncludedInPrimsolPayableGross" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_PrimsolBusinessPurchaseIncludedInPrimsolPayableGross" />

  <element name="BusinessCombinationConsiderationTransferredInventory" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_BusinessCombinationConsiderationTransferredInventory" />

  <element name="BusinessCombinationConsiderationTransferredProductInventory" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_BusinessCombinationConsiderationTransferredProductInventory" />

  <element name="BusinessCombinationConsiderationTransferredWorkInProcessInventory" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_BusinessCombinationConsiderationTransferredWorkInProcessInventory" />

  <element name="AmpioBoardAndEmployeesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_AmpioBoardAndEmployeesMember" />

  <element name="InterestPayableRelatedPartiesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_InterestPayableRelatedPartiesCurrent" />

  <element name="StockSubscription" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_StockSubscription" />

  <element name="AdjustmentsToAdditionalInCapitalBusinessCombinationLiabilitiesPaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_AdjustmentsToAdditionalInCapitalBusinessCombinationLiabilitiesPaid" />

  <element name="DebtInstrumentMaturityPeriod1" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_DebtInstrumentMaturityPeriod1" />

  <element name="AdjustmentToAdditionalPaidInCapitalOptionsPaidPursuantToMerger" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_AdjustmentToAdditionalPaidInCapitalOptionsPaidPursuantToMerger" />

  <element name="ReverseMergerValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_ReverseMergerValue" />

  <element name="ReverseMergerShare" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_ReverseMergerShare" />

  <element name="PercentageOfAmountPaidToPlacementAgentBasedOnNotesSold" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_PercentageOfAmountPaidToPlacementAgentBasedOnNotesSold" />

  <element name="PercentageOfWarrantsToPurchaseSharesOfCommonStockEqualToGrossProceedsOfNotes" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_PercentageOfWarrantsToPurchaseSharesOfCommonStockEqualToGrossProceedsOfNotes" />

  <element name="NonRefundableRetainerFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="aytu_NonRefundableRetainerFee" />

  <element name="PercentageOfWarrantsExercisePriceEqualToEquitySecuritiesSold" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_PercentageOfWarrantsExercisePriceEqualToEquitySecuritiesSold" />

  <element name="IfConvertedMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_IfConvertedMember" />

  <element name="IfNotConvertedMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_IfNotConvertedMember" />

  <element name="IfNotRegisteredCommonStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_IfNotRegisteredCommonStockMember" />

  <element name="DebtInstrumentMaturityDateTwo" type="xbrli:dateItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_DebtInstrumentMaturityDateTwo" />

  <element name="DebtInstrumentMaturityDateThree" type="xbrli:dateItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_DebtInstrumentMaturityDateThree" />

  <element name="DebtInstrumentExtensionPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_DebtInstrumentExtensionPeriod" />

  <element name="PrivatePlacementWarrantTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_PrivatePlacementWarrantTerm" />

  <element name="PrepaidResearchAndDevelopmentAndAccruedLiabilityRelatedPartiesUnpaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="aytu_PrepaidResearchAndDevelopmentAndAccruedLiabilityRelatedPartiesUnpaid" />

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  <element name="PrimsolBusinessPurchaseIncludedInPrimsolPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_PrimsolBusinessPurchaseIncludedInPrimsolPayable" />

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  <element name="BusinessAcquisitionsProFormaCostOfRevenue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="aytu_BusinessAcquisitionsProFormaCostOfRevenue" />

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  <element name="BusinessAcquisitionsProFormaInterestIncomeExpenseNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_BusinessAcquisitionsProFormaInterestIncomeExpenseNet" />

  <element name="BusinessAcquisitionsProFormaIncomeTaxExpenseBenefit" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="aytu_BusinessAcquisitionsProFormaIncomeTaxExpenseBenefit" />

  <element name="EstimatedSalesReturnsAndAllowancesPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_EstimatedSalesReturnsAndAllowancesPolicyTextBlock" />

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  <element name="ProstascintInventoryTransferFeeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_ProstascintInventoryTransferFeeMember" />

  <element name="AytuManufacturingAndCommercialDevelopmentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_AytuManufacturingAndCommercialDevelopmentMember" />

  <element name="PotentialMilestonePaymentsReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="aytu_PotentialMilestonePaymentsReceivable" />

  <element name="PercentageOfRoyaltyRateOfNetSales" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_PercentageOfRoyaltyRateOfNetSales" />

  <element name="AgreementExpirationPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_AgreementExpirationPeriod" />

  <element name="SummaryOfSignificantAccountingPoliciesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="aytu_SummaryOfSignificantAccountingPoliciesTable" />

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  <element name="BusinessAcquisitionPaidToClosingPrice" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="aytu_BusinessAcquisitionPaidToClosingPrice" />

  <element name="BusinessAcquisitionAdditionalPayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="aytu_BusinessAcquisitionAdditionalPayments" />

  <element name="PaymentsForSubmissionOfWorkOrder" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="aytu_PaymentsForSubmissionOfWorkOrder" />

  <element name="BiovestInternationalIncMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_BiovestInternationalIncMember" />

  <element name="FiniteLivedIntangibleAssetsExpirationDate" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_FiniteLivedIntangibleAssetsExpirationDate" />

  <element name="ConvertibleNotesPrincipalAmountRemainOutstanding" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="aytu_ConvertibleNotesPrincipalAmountRemainOutstanding" />

  <element name="SharesIssuableOnConvertibleNotesAsPercentageToSharesOutstandingSubsequent" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="aytu_SharesIssuableOnConvertibleNotesAsPercentageToSharesOutstandingSubsequent" />

  <element name="ClassOfWarrantOrRightExercisablePeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="aytu_ClassOfWarrantOrRightExercisablePeriod" />
</schema>

