<SEC-DOCUMENT>0001213900-18-002353-index.html : 20180228
<SEC-HEADER>0001213900-18-002353.hdr.sgml : 20180228
<ACCEPTANCE-DATETIME>20180227214009
ACCESSION NUMBER:		0001213900-18-002353
CONFORMED SUBMISSION TYPE:	S-1/A
PUBLIC DOCUMENT COUNT:		16
FILED AS OF DATE:		20180228
DATE AS OF CHANGE:		20180227

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AYTU BIOSCIENCE, INC
		CENTRAL INDEX KEY:			0001385818
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				470883144
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	FILING VALUES:
		FORM TYPE:		S-1/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-222994
		FILM NUMBER:		18647911

	BUSINESS ADDRESS:	
		STREET 1:		373 INVERNESS PARKWAY
		STREET 2:		SUITE 206
		CITY:			ENGLEWOOD
		STATE:			CO
		ZIP:			80112
		BUSINESS PHONE:		(720) 437-6580

	MAIL ADDRESS:	
		STREET 1:		373 INVERNESS PARKWAY
		STREET 2:		SUITE 206
		CITY:			ENGLEWOOD
		STATE:			CO
		ZIP:			80112

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AYTU BIOSCIENCE, INC.
		DATE OF NAME CHANGE:	20150609

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Rosewind CORP
		DATE OF NAME CHANGE:	20070110
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-1/A
<SEQUENCE>1
<FILENAME>fs12018a4_aytubioscience.htm
<DESCRIPTION>AMENDMENT NO.4 TO FORM S-1
<TEXT>
Document 1 - file: fs12018a4_aytubioscience.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-1.1
<SEQUENCE>2
<FILENAME>fs12018a4ex1-1_aytubio.htm
<DESCRIPTION>FORM OF UNDERWRITING AGREEMENT BY AND BETWEEN THE COMPANY AND JOSEPH GUNNAR & CO., LLC AS REPRESENTATIVE OF THE SEVERAL UNDERWRITERS NAMED THEREIN
<TEXT>
Document 2 - file: fs12018a4ex1-1_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>fs12018a4ex5-1_aytubio.htm
<DESCRIPTION>OPINION OF SICHENZIA ROSS FERENCE KESNER LLP
<TEXT>
Document 3 - file: fs12018a4ex5-1_aytubio.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>image_001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: image_001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>cover.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: cover.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>image_002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: image_002.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>image_003.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 7 - file: image_003.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>8
<FILENAME>image_004.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 8 - file: image_004.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>9
<FILENAME>image_005.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 9 - file: image_005.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>10
<FILENAME>image_006.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 10 - file: image_006.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>11
<FILENAME>image_007.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 11 - file: image_007.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>12
<FILENAME>image_008.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 12 - file: image_008.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>13
<FILENAME>image_009.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 13 - file: image_009.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>14
<FILENAME>image_010.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 14 - file: image_010.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>15
<FILENAME>image_011.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 15 - file: image_011.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>16
<FILENAME>image_012.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 16 - file: image_012.jpg

</DOCUMENT>
</SEC-DOCUMENT>